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A Prospective muLticEnter Registry in chrONic coronARy synDrOme

NCT06198673 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2024-01-10

No results posted yet for this study

Summary

In patients with chronic coronary syndrome (CCS), clopidogrel has a class I/A indication in patients undergoing elective percutaneous coronary intervention (PCI). Although unproven, the possibility exists that clopidogrel does not yield an optimal platelet inhibition in multiple real-world scenarios that challenge current recommendations.

The aim of this prospective observational study io assess in a consecutive unselected series of patients with CCS undergoing elective PCI the frequency of the following real world clinical scenarios:

* No pretreatment at time of PCI ('naïve')
* Evidence of incomplete responsiveness to clopidogrel
* Indication to a complex PCI.

We expect to demonstrate:

* A not negligible proportion of patients with CCS are 'naïve' at time of elective PCI in clinical practice and require a rapid onset of P2Y12 inhibition.
* A substantial proportion of patients with CCS who are treated with clopidogrel prior to elective PCI have high platelet responsiveness at time of the procedure.
* A complex PCI is performed in a substantial proportion of patients with CCS.

Conditions

Interventions

DRUG

Antiplatelet Agents

Antiplatelet agents more commonly used at time of percutaneous coronary intervention in patients with chronic coronary syndrome

Sponsors & Collaborators

  • University of Roma La Sapienza

    lead OTHER

Principal Investigators

  • Francesco Pelliccia, MD · University Sapienza

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-01-01
Primary Completion
2025-12-31
Completion
2026-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06198673 on ClinicalTrials.gov