Real-world Evaluation of BEOVU (Brolucizumab) Effectiveness and Durability for Treatment of Neovascular (Wet) Age-related Macular Degeneration (AMD)
NCT06184360 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2079
Last updated 2023-12-28
Summary
This was a retrospective, observational cohort study. Data were analyzed from the Intelligent Research in Sight (IRIS) registry from October 8, 2019, through November 26, 2021, with a follow-up period of 12 months following the first brolucizumab injection (index date).
Conditions
Sponsors & Collaborators
- lead INDUSTRY
Principal Investigators
-
Novartis Pharmaceuticals · Novartis Pharmaceuticals
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2022-05-31
- Primary Completion
- 2022-06-30
- Completion
- 2022-12-16
Countries
- United States
Study Locations
More Related Trials
-
Study to Assess the EffectiVeness of exIsting Anti-vascular Endothelial groWth Factor (Anti-VEGF) Treatment Regimens in Patients With Wet Age-related Macular Degeneration
NCT01933152 ·Status: COMPLETED
-
Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy
NCT05666804 ·Status: COMPLETED ·Phase: PHASE3
-
Evaluation of the Usefulness of a Treat and Extend Regimen Using Ranibizumab for Neovascular AMD.
NCT02321839 ·Status: COMPLETED ·Phase: PHASE4
-
Analysis of Imaging Features From Patients Treated With Brolucizumab in the Post-marketing Setting With Reports of Retinal Vasculitis and/or Retinal Vascular Occlusion
NCT05657158 ·Status: COMPLETED
-
Ranibizumab Intravitreal Injections Versus Sham Control in Patients With Branch Retinal Vein Occlusion (BRVO)
NCT01976338 ·Status: COMPLETED ·Phase: PHASE3
-
Systemic Vascular Endothelial Growth Factor (VEGF) Protein Dynamics Following Intravitreal Injections of Ranibizumab Versus Aflibercept in Patients With Neovascular Age-related Macular Degeneration
NCT02257632 ·Status: COMPLETED ·Phase: PHASE4
-
601 Versus Ranibizumab in Patients With Branch Retinal Vein Occlusion (BRVO)
NCT04667897 ·Status: COMPLETED ·Phase: PHASE2
-
Treatment -Resistant Neovascular Age-Related Macular Degeneration
NCT02332941 ·Status: COMPLETED ·Phase: PHASE1
-
Treatment Patterns With Brolucizumab in Germany - a Retrospective Cohort Study Based on Longitudinal Prescription Data: REALIZE Study
NCT06021366 ·Status: COMPLETED
-
Bevacizumab Versus Ranibizumab in Age Related Macular Degeneration
NCT01014468 ·Status: UNKNOWN ·Phase: PHASE3
-
Extended Follow-up of Patients With Macular Edema Due to Retinal Vein Occlusion
NCT01198327 ·Status: COMPLETED ·Phase: PHASE3
-
Randomized Study for Efficacy and Safety of Ranibizumab 0.5mg in Treat-extend and Monthly Regimens in Patients With nAMD
NCT01948830 ·Status: COMPLETED ·Phase: PHASE3
-
Indocyanine Angiographic Changes of Choroidal Neovascularization by Ranibizumab
NCT01810042 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy Study of Ranibizumab on Patients With Age-related Macular Degeneration.
NCT01831947 ·Status: COMPLETED ·Phase: PHASE4
-
Efficacy and Safety of Ranibizumab in Patients With Subfoveal Choroidal Neovascularization (CNV) Secondary to Age-related Macular Degeneration (AMD)
NCT00275821 ·Status: COMPLETED ·Phase: PHASE3
-
Prevention of Vision Loss in Patients With Age-Related Macular Degeneration (AMD) by Intravitreal Injection of Bevacizumab and Ranibizumab
NCT00559715 ·Status: UNKNOWN ·Phase: PHASE3
-
A Clinical Effectiveness Study Examining the Efficacy and Safety of ONS-5010 in Subjects With Neovascular Age-related Macular Degeneration (AMD)
NCT03834753 ·Status: COMPLETED ·Phase: PHASE3
-
Combination of Intravitreal Ranibizumab With or Without Macular Laser Photocoagulation for ME Secondary to BRVO
NCT03054766 ·Status: COMPLETED ·Phase: NA
-
Efficacy and Safety of Ranibizumab Intravitreal Injections Versus Dexamethasone Intravitreal Implant in Patients With Branch Retinal Vein Occlusion (BRVO)
NCT01396057 ·Status: COMPLETED ·Phase: PHASE3
-
LUCAS (Lucentis Compared to Avastin Study)
NCT01127360 ·Status: COMPLETED ·Phase: PHASE4
-
Comparison of the Time to Recurrence Between Ranibizumab and Aflibercept
NCT02126904 ·Status: UNKNOWN
-
Observational Study to Evaluate and Compare the Rate and Extent of Inflammation After a Single Intravitreal Injection of Ranibizumab vs. a Single Intravitreal Injection of Aflibercept in Treatment Naive and Treatment Experienced Patients.
NCT01942213 ·Status: COMPLETED
-
A Study to Evaluate the Neovista Ophthalmic System for the Treatment of Subfoveal CNV in Patients With AMD That Have Failed Primary Anti-VEGF Therapy
NCT00679445 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of the Efficacy and Safety of Ranibizumab Injection in Patients With Macular Edema Secondary to Branch Retinal Vein Occlusion (BRAVO)
NCT00486018 ·Status: COMPLETED ·Phase: PHASE3
-
A Proof-of-Concept Study of Faricimab (RO6867461) in Participants With Choroidal Neovascularization (CNV) Secondary to Age-Related Macular Degeneration (AMD)
NCT02484690 ·Status: COMPLETED ·Phase: PHASE2