Efficacy and Safety of Combined With Immunotherapy After Induction Therapy With Chemotherapy and Targeted Therapy in the First-line Treatment of Microsatellite Stable (MSS) Initially Unresectable Metastatic Colorectal Cancer
NCT06176885 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 36
Last updated 2023-12-27
Summary
The goal of this clinical trial is to explore the feasibility of a new mode of chemotherapy and bevacizumab induction therapy combined with immunotherapy as first-line treatment for patients with initially unresectable metastatic colorectal cancer (MSS). The main questions it aims to answer are:
1. To explore the efficacy and safety of this treatment mode
2. Try to study treatment benefit the characteristics of the crowd Participants will combined with immunotherapy after chemotherapy and bevacizumab induction therapy.
Conditions
Interventions
- DRUG
-
Camrelizumab
Combination therapy with Camrelizumab monoclonal antibody will be administered after the initial two cycles of induction therapy.
Sponsors & Collaborators
-
yue junhan
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-12-20
- Primary Completion
- 2025-12-20
- Completion
- 2026-12-20
Countries
- China
Study Locations
More Related Trials
-
FOLFOXIRI Compared to FOLFOX in First Line Treatment of Metastatic Colorectal Cancer
NCT02128425 ·Status: UNKNOWN ·Phase: PHASE2
-
mFOLFOXIRI Plus PD-1 Inhibitor vs mFOLFOX6 as Neoadjuvant Therapy for Locally Advanced Colon Cancer
NCT06890624 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer
NCT00003001 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Safety and Efficacy Study of MEHD7945A + FOLFIRI Versus Cetuximab + FOLFIRI as Second Line Therapy in Participants With KRAS Wild-Type Metastatic Colorectal Cancer (mCRC)
NCT01652482 ·Status: COMPLETED ·Phase: PHASE2
-
Testing the Addition of an Anti-Cancer Drug, Abemaciclib, to the Usual Chemotherapy Treatment (5-Fluorouracil) for Metastatic, Refractory Colorectal Cancer
NCT06654037 ·Status: RECRUITING ·Phase: PHASE1
-
AK112 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI as Second-line Treatment of MSS/pMMR Metastatic Colorectal Cancer
NCT07021950 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Cetuximab Plus Combination Chemotherapy in Treating Patients With Stage IV Colorectal Cancer
NCT00020917 ·Status: COMPLETED ·Phase: PHASE2
-
First-Line Treatment Induced With mFOLFOX6 and HLX04 Regimen, Following Combined With Serplulimab in MSS Initially Unresectable Metastatic Colorectal Cancer
NCT06491355 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Phase II Trial of FOLFOXIGIL Versus FOLFOXIRI as First-line Therapy in Patients With mCRC
NCT03222089 ·Status: WITHDRAWN ·Phase: PHASE2
-
Immune Checkpoint Inhibitors + Chemotherapy Versus Chemotherapy in the Neoadjuvant Treatment of Locally Advanced Colorectal Cancer
NCT06154538 ·Status: RECRUITING ·Phase: PHASE2
-
FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer
NCT05627635 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1/PHASE2
-
Study of Encorafenib + Cetuximab Plus or Minus Binimetinib vs. Irinotecan/Cetuximab or Infusional 5-Fluorouracil (5-FU)/Folinic Acid (FA)/Irinotecan (FOLFIRI)/Cetuximab With a Safety Lead-in of Encorafenib + Binimetinib + Cetuximab in Patients With BRAF V600E-mutant Metastatic Colorectal Cancer
NCT02928224 ·Status: COMPLETED ·Phase: PHASE3
-
QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma
NCT00813605 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Ametumumab in Combination With Anti-PD-1 Monoclonal Antibody and FOLFIRI in Patients With RAS Wild-type Advanced Colorectal Cancer
NCT05684211 ·Status: UNKNOWN ·Phase: PHASE2
-
Clinical Trial of an Anti-cancer Drug, CA-4948 (Emavusertib), in Combination With Chemotherapy Treatment (FOLFOX Plus Bevacizumab) in Metastatic Colorectal Cancer
NCT06696768 ·Status: RECRUITING ·Phase: PHASE1
-
Cetuximab Plus FOLFOXIRI vs Cetuximab Plus FOLFOX For CRCLM
NCT03493048 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Amivantamab and FOLFIRI Versus Cetuximab/Bevacizumab and FOLFIRI in Participants With KRAS/NRAS and BRAF Wild-type Colorectal Cancer Who Have Previously Received Chemotherapy
NCT06750094 ·Status: RECRUITING ·Phase: PHASE3
-
Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer
NCT00006115 ·Status: UNKNOWN ·Phase: PHASE2
-
Maintenance Metronomic Chemotherapy for Metastatic Colorectal Carcinoma
NCT01668680 ·Status: TERMINATED ·Phase: PHASE2
-
Hepatic Arterial Infusion of Floxuridine, Gemcitabine Hydrochloride, and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer Previously Treated With Surgery
NCT00645710 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Regorafenib Plus FOLFIRI With Irinotecan Dose Escalated in Patients With Previously Treated Metastatic Colorectal Cancer
NCT03880877 ·Status: UNKNOWN ·Phase: PHASE2
-
Phase II Study Comparing Conversion Rate to Surgery With Hepatic Arterial Infusion Chemotherapy to Systemic Chemotherapy in Patients With Non Resectable Liver-only Colorectal Metastases
NCT05103020 ·Status: UNKNOWN ·Phase: PHASE2
-
Regorafenib+FOLFIRI Versus Placebo+FOLFIRI as 2nd Line Tx in Metastatic Colorectal Cancer
NCT01298570 ·Status: COMPLETED ·Phase: PHASE2
-
Trifluridine/Tipiracil Plus Regorafenib vs Trifluridine/Tipiracil Plus Bevacizumab for Refractory Metastatic Colorectal Cancer
NCT06992648 ·Status: RECRUITING ·Phase: PHASE3
-
The Phase 1b/IIa, Open-label, Dose Escalation and Dose Expansion to Evaluate Safety, Tolerability, and Preliminary Efficacy of the Combination of HCB101, Cetuximab/Bevacizumab, and FOLFOX/FOLFIRI in Advanced or Metastatic Colorectal Cancer
NCT07204574 ·Status: RECRUITING ·Phase: PHASE1/PHASE2