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Developing Allogeneic Musculoskeletal Therapies

NCT06167928 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 325

Last updated 2025-03-06

No results posted yet for this study

Summary

The goal of this observational study is to analyse the cartilage and bone forming potential of cells isolated from the tissues of patients undergoing surgery for the treatment of polydactyly, hip dislocation and from other bio-banked cartilage tissues. The main question it aims to answer is:

Which of the following tissues from polydactyly digit, iliac apophysis or other bio-banked cartilage produce better cartilage in vitro and in vivo? Participants receiving digit amputation surgery for treatment of polydactyly will be asked to donate the associated waste tissue whilst participants receiving surgery to treat a dislocated hip will be asked to donate an extra small piece of cartilage tissue (approximately 1 gram) from the iliac apophysis. Other tissues for the study will be obtained from those donated to biobanks.

Conditions

Sponsors & Collaborators

  • Alder Hey Children's NHS Foundation Trust

    collaborator OTHER

  • Birmingham Women's and Children's NHS Foundation Trust

    collaborator OTHER

  • Norfolk and Norwich University Hospitals NHS Foundation Trust

    collaborator OTHER

  • Royal National Orthopaedic Hospital NHS Trust

    collaborator OTHER

  • Scottish National Blood Transfusion Service

    collaborator UNKNOWN

  • NHS Blood and Transplant

    collaborator OTHER_GOV

  • University of Birmingham

    collaborator OTHER

  • Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust

    collaborator OTHER_GOV

  • The Royal Orthopaedic Hospital NHS Trust

    collaborator OTHER

  • Keele University

    lead OTHER

Principal Investigators

  • Karina T Wright, PhD · ISTM, Keele University

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-08
Primary Completion
2028-06-30
Completion
2037-09-01

Countries

  • United Kingdom

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06167928 on ClinicalTrials.gov