Chidamide Combined With Linperlisibon for the Treatment of Refractory/Relapsed Follicular Lymphoma
NCT06158386 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 33
Last updated 2025-02-19
Summary
To observe the safety and efficacy of Chidamide combined with Linperlisib in the treatment of refractory and relapsed follicular lymphoma.
Conditions
- Follicular Lymphoma
- Refractory B-Cell Lymphoma
- Relapsed Non-Hodgkin Lymphoma
Interventions
- DRUG
-
Chidamide combined with Linperlisib
Specified dose on specified days: Cedarbenzamide (C) 20mg orally twice weekly, Limplica (L) 80mg once daily, 2 weeks on 2 weeks off, Repeat on day 28.
Sponsors & Collaborators
-
Fujian Provincial Hospital
collaborator OTHER -
Fujian Cancer Hospital
collaborator OTHER_GOV -
Zhangzhou Affiliated Hospital of Fujian Medical University
collaborator OTHER -
Jieyang People's Hospital
collaborator OTHER -
Dongguan People's Hospital
collaborator OTHER_GOV -
Huizhou Municipal Central Hospital
collaborator OTHER -
The First Affiliated Hospital with Nanjing Medical University
collaborator OTHER -
Sun Yat-sen University
collaborator OTHER -
Shanxi Province Cancer Hospital
collaborator OTHER -
The First Affiliated Hospital of Xiamen University
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- FEMALE
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-11-22
- Primary Completion
- 2027-12-31
- Completion
- 2027-12-31
Countries
- China
Study Locations
More Related Trials
-
Safety Profile of Idelalisib in Patients With Refractory Follicular Lymphoma
NCT03568929 ·Status: COMPLETED
-
Chidamide Plus Golidocitinib in Relapsed/Refractory Peripheral T-Cell Lymphoma
NCT06757387 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
Study to Investigate Idelalisib in Combination With Chemotherapeutic Agents, Immunomodulatory Agents and Anti-CD20 Monoclonal Antibody (mAb) in Participants With Relapsed or Refractory Indolent B-cell Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma or Chronic Lymphocytic Leukemia
NCT01088048 ·Status: COMPLETED ·Phase: PHASE1
-
Chidamide for Refractory/Relapsed Peripheral T Cell Lymphoma
NCT02944812 ·Status: UNKNOWN ·Phase: PHASE2
-
Linperlisib Combined With Immunochemotherapy in Relapsed/Refractory LBCL
NCT06489808 ·Status: RECRUITING ·Phase: PHASE2
-
Chidamide in Combination With Decitabine in Non-Hodgkin's Lymphoma Relapsed After Chimeric Antigen Receptor
NCT04337606 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Study of OBINUTUZUMAB Combined to LENALIDOMIDE for the Treatment of Relapsed/Refractory Follicular and Aggressive B-cell Lymphoma
NCT01582776 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Axicabtagene Ciloleucel Injection in Patients With Relapsed/Refractory Follicular Lymphoma
NCT06826118 ·Status: RECRUITING ·Phase: PHASE2
-
Linperlisib Combined With Chidamide in Patients With PTCL
NCT06421948 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Chidamide + R-GemOx Regimen as Salvage Treatment for Transplant-ineligible Patients With Relapsed/Refractory DLBCL
NCT04022005 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Chidamide, Decitabine and Immune Checkpoint Inhibitors in R/R NHL and Advanced Solid Tumors
NCT05320640 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
A Study of GFH009 Monotherapy in Patients with Relapsed or Refractory Peripheral T-cell Lymphoma (PTCL)
NCT05934513 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Lenalidomide and Idelalisib in Treating Patients With Recurrent Follicular Lymphoma
NCT01644799 ·Status: COMPLETED ·Phase: PHASE1
-
A Phase II Study of SHR2554 in Patients With Relapsed or Refractory Follicular Lymphoma
NCT06368167 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
Chiauranib in Combination With Chidamide in Patients With Relapsed/Refractory Non-Hodgkin's Lymphoma
NCT03974243 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Lenalidomide and Gemcitabine in Relapsed or Refractory Peripheral T-cell Lymphomas
NCT05105412 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Safety and Efficacy Study of Duvelisib in Relapsed/Refractory Follicular Lymphoma
NCT04707079 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Axicabtagene Ciloleucel Versus Standard of Care Therapy in Participants With Relapsed/Refractory Follicular Lymphoma
NCT05371093 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Linperlisib Combination With Cyclophosphamide, Prednisone, and Thalidomide (CPT) in R/R NHL
NCT07195799 ·Status: RECRUITING ·Phase: PHASE2
-
Chidamide Maintenance After Autologous Hematopoietic Stem Cell Transplantation for Relapsed, Refractory or High-risk Lymphoma
NCT03611231 ·Status: UNKNOWN ·Phase: PHASE2
-
A Phase 2 Clinical Study of YY-20394 in Patients With Relapsed/Refractory Follicular Lymphoma
NCT04379167 ·Status: UNKNOWN ·Phase: PHASE2
-
Study of Chidamide as a Single-agent Treatment for Patients With Relapse or Refractory B-NHL
NCT03245905 ·Status: UNKNOWN ·Phase: PHASE2
-
A Study Evaluating the Safety and Efficacy of Atezolizumab in Combination With Obinutuzumab Plus Lenalidomide in Patients With Relapsed or Refractory Follicular Lymphoma
NCT02631577 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
HMPL-760 in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma
NCT05190068 ·Status: COMPLETED ·Phase: PHASE1
-
Clinical Study of Mitoxantrone Hydrochloride Liposome Injection vs. Chidamide in Patients With Relapsed/Refractory PTCL
NCT04668690 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3