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Exercise and Emotional Learning in Posttraumatic Stress Disorder

NCT06127342 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2025-09-03

No results posted yet for this study

Summary

The goal of this clinical trial is to test how exercise affects learning and memory processes relevant to the treatment of PTSD. Participants will complete a baseline intake followed by two experimental sessions. During the first experimental session, participants will undergo an MRI session of imaginal exposure to traumatic memory cues followed by 30-minutes of moderate intensity exercise or low intensity exercise. Participants will complete a second session of imaginal exposure with MRI 24 hours later.

Conditions

Interventions

BEHAVIORAL

Moderate Intensity Exercise

Participants will wear a heartrate monitor and cycle on a stationary bike at a slow speed for 5 minutes, then slowly cycle on a stationary bike for 30 minutes, then cycle on the stationary bike at a slow speed for 5 minutes.

BEHAVIORAL

Low Intensity Exercise

Participants will wear a heartrate monitor and cycle on a stationary bike at a slow speed for 40 minutes.

Sponsors & Collaborators

  • University of Texas at Austin

    collaborator OTHER

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Christal L Badour

    lead OTHER

Principal Investigators

  • Thomas G Adams, Jr., PhD · University of Kentucky

  • Christal Badour, PhD · University of Kentucky

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
64 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-05-13
Primary Completion
2026-09-30
Completion
2026-11-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06127342 on ClinicalTrials.gov