Safety and Efficacy of Metabolically Armed CD19 CAR-T Cells (Meta10-19) in the Treatment of r/r DLBCL Clinical Research
NCT06120166 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 18
Last updated 2025-09-19
Summary
A Study of Metabolically Armed CD19 CAR-T Cells Therapy for Patients With Relapsed and/or Refractory Diffuse Large B-Cell Lymphoma
Conditions
- Diffuse Large B-cell Lymphoma
Interventions
- DRUG
-
Metabolically Armed CD19 CAR-T cells
Each subject receive metabolically armed CD19 CAR-T cells by intravenous infusion
Sponsors & Collaborators
-
Leman Biotech Co., Ltd.
collaborator INDUSTRY -
He Huang
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-11-16
- Primary Completion
- 2025-12-01
- Completion
- 2026-04-05
Countries
- China
Study Locations
More Related Trials
-
CD19-targeted CAR T Cells for Relapsed and Refractory (R/R) Large B-cell Lymphoma
NCT06149169 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
CAR-T Treatment for Relapse / Refractory Type Safety and Effectiveness of Lymphoma
NCT03488160 ·Status: UNKNOWN ·Phase: NA
-
Modified CD19 CAR-T in Patients With Relapsed or Refractory CD19+ B-cell Malignancies
NCT04684472 ·Status: UNKNOWN ·Phase: PHASE1
-
Anti-CD19 CAR-Engineered NK Cells in the Treatment of Relapsed/Refractory B-cell Malignancies
NCT05410041 ·Status: UNKNOWN ·Phase: PHASE1
-
A Study of C-CAR066 in Subjects With r/r Diffuse Large B Cell Lymphoma Who Received CD19 CAR-T Therapy
NCT04316624 ·Status: COMPLETED ·Phase: PHASE1
-
CD19/20 Bispecific Nanobody-derived CAR-T Cells in B Cell Lymphoma
NCT03881761 ·Status: UNKNOWN ·Phase: PHASE1
-
Safety of Autologous Humanized Anti-CD19 and Anti-CD20 Dual Specific CAR-T Cells in Adult Patients With Diffuse Large B-cell Lymphoma
NCT04215016 ·Status: UNKNOWN ·Phase: PHASE1
-
CD19+Targeted CAR-T Cell Therapy for Relapsed/Refractory CD19+ B Cell Leukemia and Lymphoma
NCT04271410 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CAR-T Cell Immunotherapy in CD19 Positive Relapsed or Refractory Leukemia and Lymphoma
NCT02819583 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CD19 and CD22 Targeted CAR-T Cell Therapy for Relapsed/Refractory B Cell Leukemia and Lymphoma
NCT04649983 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Research of CD19 Targeted CAR-T Cell in Relapsed/ Refractory B-ALL
NCT06641024 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1
-
Safety and Efficacy of Sequential CD19 and CD22 Targeted CAR-T Therapy for Relapsed/Refractory B Cell Lymphoma
NCT05651100 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1/PHASE2
-
CART-19 Cells for R/R B-cell Lymphoma
NCT03391726 ·Status: UNKNOWN ·Phase: PHASE2/PHASE3
-
The Safety and Efficacy of CART-19 Cells in Relapse and Refractory Patients With CD19+ B-cell Lymphoma
NCT03101709 ·Status: UNKNOWN ·Phase: PHASE1
-
Safety and Efficacy of CD19 and CD22 Targeted CAR-T Therapy for Relapsed/Refractory B Cell Leukemia and Lymphoma
NCT04648475 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Safety and Efficacy of CD19-Targeted CAR-T Therapy for Relapsed/Refractory CD19+ B Cell Leukemia and Lymphoma
NCT04271800 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
CART-19 FOR Relapsed/Refractory Acute Lymphoblastic Leukemia (ALL)
NCT03544021 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Anti-CD19 CAR-T Cells for Relapsed or Refractory Acute Lymphoblastic Leukemia and Lymphomas
NCT04196205 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
a Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B Cell Lymphoma
NCT04782193 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Phase I Study of pCAR-19B in the Treatment of Adult CD19-positive Relapsed/Refractory B-ALL
NCT04888442 ·Status: UNKNOWN ·Phase: PHASE1
-
CD19-directed CAR T Cells Therapy in Relapsed/Refractory B Cell Malignancy
NCT02537977 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Clinical Trial to Evaluate the Safety and Efficacy of IM19 CAR-T Cells in Patients With Relapsed and Refractory (R/R) B-cell Acute Lymphoblastic Leukemia
NCT05480501 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Safety and Efficiency Study of CD19-PD1-CART Cell in Relapsed/Refractory B Cell Lymphoma
NCT04163302 ·Status: UNKNOWN ·Phase: PHASE2
-
Safety and Efficacy of CD19/CD22 Dual Targeted CAR-T Cell Therapy in R/R B-Cell Acute Lymphoblastic Leukemia
NCT05225831 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Exploratory Clinical Study of CD19-targeted CAR-T and CAR-DC in the Treatment of Relapsed and Refractory B-cell Lymphoma
NCT05585996 ·Status: RECRUITING ·Phase: PHASE1