Health Status of Children Born After Assisted Reproductive Technologies

Summary

The goal of this observational study is to study the features of psychophysical development and the morbidity patterns of children born after assisted pregnancy, and to identify the connection with the health status of mothers, followed by the development of a prediction model and general principles of management of children born after ART. The main questions it aims to answer are: • the influence of premorbid background of mothers on children's physical development, disease occurrence and morbidity patterns of children born as after ART.

* To identify the indicators of cellular and humoral immunity in children born after different oocyte fertilization methods in IVF programs (classical IVF or ICSI).
* To study the long-term effects of ART on the endocrine status of children.

It will be studied hemogram examination, immunity indicators (cellular components CD3, CD4, CD8, CD16, CD20, CD25, CD95, CD3 HLA DR+, CD# HLA-DR; humoral components - IgM, IgA, IgE, IgG) and laboratory investigations in endocrine system (TSH, free T3 and T4 levels, insulin, insulin-like growth factor-1 (IGF-1), somatotropic hormone (STH); glucose, potassium, sodium) in 120 children born after ART. Researchers will compare 132 children conceived spontaneously to see if ART can influent on the health status in future.

Conditions

• Children Born After Assisted Reproductive Technologies
• Health Status
• Child Development

Interventions

DIAGNOSTIC_TEST

hemogram examination

It will be studied hemogram examination, immunity indicators (cellular components CD3, CD4, CD8, CD16, CD20, CD25, CD95, CD3 HLA DR+, CD# HLA-DR; humoral components - IgM, IgA, IgE, IgG) and laboratory investigations in endocrine system (TSH, free T3 and T4 levels, insulin, insulin-like growth factor-1 (IGF-1), somatotropic hormone (STH); glucose, potassium, sodium) in 120 children born after ART. Researchers will compare 132 children conceived spontaneously to see if ART can influent on the health status in future.

Sponsors & Collaborators

• Vyacheslav Notanovich Lokshin

  collaborator UNKNOWN

• Nurgalieva Zhanar Zhenisovna

  collaborator UNKNOWN

• Manzhuova Lyazzat Nurbapayevna

  collaborator UNKNOWN

• Abshekenova Aigerim Temirkhanovna

  collaborator UNKNOWN

• Valeria Nekhorosheva

  collaborator UNKNOWN

• Kusainova Farida Azimovna

  collaborator UNKNOWN

• Kazakhstan's Medical University "KSPH"

  lead OTHER

Principal Investigators

• Sevara K Ilmuratova · Kazakhstan Medical University "KSPH"

• Vyacheslav Lokshin, PhD · International Clinical Centre of Reproduction "PERSONA"

• Lyazzat Manzhuova, PhD · Scientific Center of Pediatrics and Pediatric Surgery

• Zhanar Nurgaliyeva, PhD · Asfendiyarov Kazakh National Medical University

• Farida Kussainova, MD · Asfendiyarov Kazakh National Medical University

• Аygul Bazarbaeva, MD · Scientific Center of Pediatrics and Pediatric Surgery

• Valeriya Nekhorosheva, MD · Institute of Reproductive Medicine

• Aygerim Abshekenova, MD · International Clinical Centre of Reproduction "PERSONA"

Eligibility

Min Age

1 Month

Max Age

60 Months

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2023-10-18

Primary Completion

2024-01-19

Completion

2024-01-22

Countries

• Kazakhstan

Study Locations