The Effect of Jiajian Guishen Granules on the Modulation of Ovarian Function in Patients With Poor Ovarian Response(POR)

Summary

Relying on the Department of Gynecology of Dongzhimen Hospital of Beijing University of Traditional Chinese Medicine and chaoyang hospital of Capital medical university, this randomized controlled clinical study was carried out to investigate the application of kidney tonifying herbs to patients with poor ovarian response（POR）.

A total of 76 patients with POR were collected and stratified district groups were randomly divided into a test group and a control group, with 38 patients included in each group. The experimental group was intervented with JJGS granules + coenzyme Q10 simulant, and the control group was intervened with coenzyme Q10 + JJGS granules simulant. AMH, serum basal sex hormone, AFC, TCM syndrome score, modified Kupperman scale and pregnancy status were observed before and after treatment to investigate the effects of Jiajian Guishen granules on the ovarian function of POR patients.

Conditions

• Poor Ovarian Response

Interventions

DRUG

Jiajian Guishen granules

This study was a stratified district group randomized, double-blind, double simulation, positive control clinical trial with JJGS granules + coenzyme Q10 simulant in the test group and JJGS granules simulant + coenzyme Q10 in the control group

DRUG

coenzyme Q10

This study was a stratified district group randomized, double-blind, double simulation, positive control clinical trial with JJGS granules + coenzyme Q10 simulant in the test group and JJGS granules simulant + coenzyme Q10 in the control group

Sponsors & Collaborators

• Capital Medical University

  collaborator OTHER

• Shi Yun

  lead OTHER

Principal Investigators

• Shi Y Shi Yun, phD · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Wang CM Wang Chunmei, phD · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Shi X Shi Xiao, phD · Capital Medical University

• Yang QH Yang Qiaohui, pdD · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Yan QY Yan Qingya, phD · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Shao JY Shao Jingyi, Master · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Xu K Xu Ke, Master · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Li XY Li Xiyu, Bachelor · Dongzhimen Hospital of Beijing University of Chinese Medicine

• Liu QY Liu Qinyang, Bachelor · Dongzhimen Hospital of Beijing University of Chinese Medicine

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

20 Years

Max Age

45 Years

Sex

FEMALE

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-06-01

Primary Completion

2025-08-31

Completion

2025-08-31

Countries

• China

Study Locations