Fatal Overdose Review Teams - Research to Enhance Surveillance Systems
NCT06084221 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 400
Last updated 2026-02-06
Summary
This project seeks to address the overdose epidemic by working with overdose fatality review (OFR) teams. Current OFR practices rely on a case review model where OFR teams assess one or two overdose cases to make policy and program recommendations. However, the continued rise in overdose rates and number of preventable overdose deaths suggest a need to shift OFR teams away from case review and toward using timely population-level data to better inform their recommendations and actions.
The goal of this project, Fatal Overdose Review Teams - Research to Enhance Surveillance Systems (FORTRESS), is to improve standard OFR practices by equipping OFRs with a data dashboard built on near real-time aggregate data, linked across multiple sources and presented in a way that helps identify common "overdose touchpoints," or opportunities to connect individuals at risk for overdose with evidence-based treatment.
During the first project phase, the FORTRESS team will design the "Overdose Touchpoints Dashboard'' (Aim 1). The FORTRESS team will also train OFR team members in "Data-Driven Decision Making" (DDDM) to effectively use the dashboard. The FORTRESS team also includes individuals involved in developing the CDC's OFR best practice guidelines and a pilot study of OFR adherence to these guidelines, which will inform the FORTRESS team's development of an "OFR Fidelity Tool'' (Aim 2). This tool will be the first of its kind.
For the second project phase, the FORTRESS team will conduct a cluster-randomized stepped-wedge trial comparing the impact of the intervention (dashboard + DDDM training) versus standard OFR practices on both implementation (Aim 3) and effectiveness outcomes (Aim 4). Implementation outcomes include implementation process fidelity (Stages of Implementation Completion), staff acceptance of harm reduction philosophies (qualitative interviews), OFR fidelity to CDC best practices (FORTRESS OFR Fidelity Tool), and usability of the Overdose Touchpoint Dashboard, (Systems Usability Scale). A statewide OFR data repository serves as a rich source of data on effectiveness outcomes, including OFR team recommendation quality and local actions to implement recommended overdose prevention strategies. The FORTRESS team will also survey OFR team members to assess changes in their attitudes toward evidence-based overdose prevention strategies. In sum, the FORTRESS team is uniquely qualified to help OFRs use more comprehensive available data to inform quality, action-oriented recommendations to reduce overdose. Funding for this project comes from the HEAL Initiative (https://heal.nih.gov/).
Conditions
- Substance-Related Disorders
- Opioid-Related Disorders
Interventions
- BEHAVIORAL
-
Data-Driven Decision Making (DDDM)
The intervention consists of providing real-time data on overdose touchpoints to OFRs and training in DDDM for continuous quality improvement cycles, leading to improved OFR recommendations and implementation of overdose prevention strategies.
- BEHAVIORAL
-
Overdose-prevention strategies inventory
A list of overdose prevention and harm reduction strategies will be provided to OFRs for possible implementation, depending on local needs and final dashboard development.
Sponsors & Collaborators
-
National Institute on Drug Abuse (NIDA)
collaborator NIH -
Indiana University
lead OTHER
Principal Investigators
-
Matthew C Aalsma, PhD · Indiana University School of Medicine
Study Design
- Allocation
- RANDOMIZED
- Purpose
- PREVENTION
- Masking
- NONE
- Model
- PARALLEL
Eligibility
- Sex
- ALL
- Healthy Volunteers
- Yes
Timeline & Regulatory
- Start
- 2023-09-21
- Primary Completion
- 2027-09-30
- Completion
- 2027-09-30
Countries
- United States
Study Locations
More Related Trials
-
An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses
NCT04212364 ·Status: COMPLETED ·Phase: NA
-
Phone Interview to Prevent Recurring Opioid Overdoses
NCT02282306 ·Status: COMPLETED ·Phase: NA
-
Clinical Decision Support to Increase Use of Medications for Opioid Use Disorder
NCT06526286 ·Status: NOT_YET_RECRUITING
-
Clinical Decision Support for Safety of Opioid Transitions
NCT06527040 ·Status: NOT_YET_RECRUITING
-
Addressing Overdose Risk Among Recently Incarcerated People Living With HIV/AIDS
NCT03569592 ·Status: COMPLETED ·Phase: NA
-
Clinician-patient Interaction During Addiction Consultation
NCT01769651 ·Status: UNKNOWN
-
Evaluation of a Medication Health Center to Promote Opioid Safety
NCT06456294 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Treatment Efficacy for Drug Abuse and AIDS Prevention - 1
NCT00000210 ·Status: COMPLETED ·Phase: PHASE2
-
Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders
NCT03241771 ·Status: COMPLETED ·Phase: NA
-
A Setting Focus Overdose Prevention Intervention
NCT05320835 ·Status: RECRUITING ·Phase: NA
-
Clinical Decision Support to Improve System Naloxone Co-prescribing
NCT06271668 ·Status: ACTIVE_NOT_RECRUITING
-
A Tailored, Peer-delivered Intervention to Reduce Recurring Opioid Overdoses
NCT02922959 ·Status: COMPLETED ·Phase: NA
-
Treatment Efficacy for Drug Abuse and AIDS Prevention - 2
NCT00000211 ·Status: COMPLETED ·Phase: PHASE2
-
Dane County Drug Court Study for Addicted Offenders
NCT01843751 ·Status: COMPLETED ·Phase: PHASE3
-
Evaluation of Clinical Decision Support in Opioid Tapering
NCT06527079 ·Status: NOT_YET_RECRUITING
-
Mobile Peer Support for OUD Recovery
NCT05405712 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Smartphones for Opiate Addiction Recovery
NCT05033028 ·Status: RECRUITING ·Phase: PHASE3
-
Buprenorphine Detoxification With Two Types of Treatment. BBD IV - 13
NCT00000231 ·Status: COMPLETED ·Phase: PHASE2
-
Community-Based, Client-Centered Prevention Homes to Address the Rural Opioid Epidemic- Aim 3
NCT04268173 ·Status: COMPLETED ·Phase: NA
-
HEALing Communities Study
NCT04111939 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Connection, Navigation, Engagement in Care and Treatment for Opioid Use Disorder
NCT04797962 ·Status: COMPLETED ·Phase: NA
-
Suicide Prediction and Prevention for People at Risk for Opioid Use Disorder: Supplement to COMPUTE 2.0
NCT04939727 ·Status: COMPLETED ·Phase: NA
-
The Rhode Island Prescription and Illicit Drug Study
NCT04372238 ·Status: COMPLETED ·Phase: NA
-
Safety & Prevention Outcomes Study
NCT01894087 ·Status: COMPLETED ·Phase: NA
-
Combined Buprenorphine and Behavioral Treatment With and Without Contingent Reinforcement on Opioid and Cocaine Abstinence. - 22
NCT00000240 ·Status: COMPLETED ·Phase: PHASE2