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Imaging Biomarkers for Myofascial Pain

NCT06060925 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 96

Last updated 2026-02-02

No results posted yet for this study

Summary

Myofascial pain syndrome (MPS) is highly prevalent in the community. It is primarily diagnosed using patient self reports and physical examination, which lack reliability, sensitivity and specificity and does not provide insights into the abnormal biological and physiological processes in soft tissues. While a number of treatment methods are available to patients, there are currently no criteria to determine which treatments might be best for each patient's unique myofascial pain phenotype. To improve evidence-based management of myofascial pain, there is a critical need to develop quantitative measures that advance the understanding of the physiological processes in the underlying the soft tissues across the clinical continuum of MPS. The objective of this project is to develop a quantitative biomarker informed by the current understanding of underlying tissue-level mechanisms at the level of the "myofascial unit" (muscle, nerve, fascia, vasculature, lymphatics) that are likely to be involved in MPS.

Conditions

  • Myofascial Pain Syndrome
  • Healthy

Interventions

DIAGNOSTIC_TEST

Ultrasound imaging

B-mode, color Doppler, shear wave elastography

DIAGNOSTIC_TEST

Bioimpedance spectroscopy

Multifrequency bioimpedance spectroscopy

DIAGNOSTIC_TEST

Electromyography

High density electromyography

DIAGNOSTIC_TEST

Physical examination

Comprehensive musculoskeletal physical examination, including range of motion, and quantitative sensory testing

Sponsors & Collaborators

  • George Mason University

    lead OTHER

Principal Investigators

  • Siddhartha Sikdar, PhD · George Mason University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-01
Primary Completion
2025-08-31
Completion
2025-08-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06060925 on ClinicalTrials.gov