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Pathological Changes in the Cardiovascular System in Valvular Heart Disease

NCT06060171 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 360

Last updated 2023-10-06

No results posted yet for this study

Summary

An observational cohort study of patients recruited presenting with valvular heart disease. The specialized investigations will focus on myocardial remodelling and scar formation/regression and extracardiac micro- and macro-vascular sequelae of valvular heart disease (VHD). The aim is to investigate the natural history of VHD and its ensuing cardiac and extracardiac end organ effects, the impact of existing interventions and the long-term outcome. We hope to establish the underlying causative aetiology of known associated conditions (e.g. vascular dementia) and to determine if extracardiac changes may serve as early biomarkers of prognosis in VHD. Participants will attend for two visits at Barts Heart Centre or Chenies Mews Imaging Centre and will undergo a panel of tests including cross-sectional cardiac imaging, point-of-care microvascular assessment and blood tests. Patient outcome will be assessed by data linkage to hospital episode statistic (HES) data and ONS data (via NHS spine). We aim to identify determinants that will help to improve patient selection and timing of valve intervention based on advanced clinical, blood and/or imaging biomarkers.

Conditions

  • Valvular Heart Disease

Interventions

PROCEDURE

Aortic valve intervention

Surgical or transcatheter aortic valve intervention

Sponsors & Collaborators

  • British Heart Foundation

    collaborator OTHER

  • Horizon 2020 - European Commission

    collaborator OTHER

  • University College, London

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-08-01
Primary Completion
2025-01-01
Completion
2025-01-01

Countries

  • United Kingdom

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06060171 on ClinicalTrials.gov