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Effect of Percussive Massage on Skeletal Muscle During Limb Immobilization

NCT06053229 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2024-08-13

No results posted yet for this study

Summary

The primary aims of this study are to determine the effect of percussive massage (30 min/session, 2 sessions/day, daily) during 10 days of unilateral limb immobilization on preserving muscle, vascular, and mitochondrial function. The following hypotheses will be tested:

Hypothesis 1: Percussive massage will attenuate the loss of size, strength and endurance over the immobilization period compared to the control group, as measured by MRI, maximal isometric and isokinetic force production and muscle endurance test using Biodex dynamometry.

Hypothesis 2: Percussive massage will attenuate the loss of vascular function and blood flow compared to the control group as measured by passive leg movement and femoral artery blood flow.

Hypothesis 3: Percussive massage will attenuate the loss of skeletal muscle mitochondrial function and decrease H2O2 production during immobilization compared to the control group, as measured by high-resolution respirometry.

Conditions

  • Massage Therapy
  • Muscular Atrophy

Interventions

DEVICE

percussive massage

30 minutes of percussive massage will be administered twice per day during the 10 day immobilization period using a percussive massage device

COMBINATION_PRODUCT

Leg Immobilization

All subjects will have their left leg immobilized using an immobilization brace for 10 days

Sponsors & Collaborators

  • Brigham Young University

    lead OTHER

Principal Investigators

  • Robert D Hyldahl, PhD · Brigham Young University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-03-01
Primary Completion
2024-12-31
Completion
2025-07-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06053229 on ClinicalTrials.gov