Enterics for Global Health (EFGH)

Summary

Diarrhea remains a leading cause of death among young children, with the majority of diarrhea deaths occurring in low- and middle-income countries. Childhood diarrhea caused by a type of bacteria called "Shigella" is responsible for an estimated 60,000 deaths each year and may cause particularly severe illness among children. Currently, there are several promising vaccines to prevent Shigella diarrhea in development, but key information is still needed to inform future vaccine studies. The purpose of this study, titled Enterics for Global Health (or the "EFGH"), is to determine the number and rate of new cases of Shigella diarrhea among children 6 to 35 months of age presenting to health facilities with diarrhea or dysentery. Over a two-year period, the EFGH study will enroll 1,400 children from each of the seven countries: Peru, Pakistan, Bangladesh, Mali, Malawi, Kenya, and The Gambia (9,800 children total).

Conditions

• Shigella
• Child
• Diarrhea

Sponsors & Collaborators

• Aga Khan University

  collaborator OTHER

• International Centre for Diarrhoeal Disease Research, Bangladesh

  collaborator OTHER

• University of Maryland, Baltimore

  collaborator OTHER

• University of Virginia

  collaborator OTHER

• Asociacion Benefica Prisma

  collaborator OTHER

• Medical Research Council Unit, The Gambia

  collaborator OTHER

• Kenya Medical Research Institute

  collaborator OTHER

• Center for Vaccine Development - Mali

  collaborator OTHER

• Malawi-Liverpool-Wellcome Trust Clinical Research Programme

  collaborator OTHER

• Bill and Melinda Gates Foundation

  collaborator OTHER

• University of Washington

  lead OTHER

Principal Investigators

• Patricia B Pavlinac, PhD · University of Washington

Eligibility

Min Age

6 Months

Max Age

35 Months

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2022-08-25

Primary Completion

2024-08-17

Completion

2025-04-30

Countries

• Bangladesh
• Kenya
• Malawi
• Mali
• Pakistan
• Peru
• The Gambia

Study Locations