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Revitalization of Traumatized Immature Permanent Teeth

NCT06043453 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 72

Last updated 2024-07-01

No results posted yet for this study

Summary

This study aims to assess the hypothesis that revitalization of teeth without (a)symptomatic apical periodontitis have a more favourable outcome in terms of further root development, periapical bone healing, maintaining/regaining pulp sensitivity and survival, than teeth with (a)symptomatic apical periodontitis.

Conditions

Interventions

OTHER

revitalization

The main idea behind revitalization is to firstly disinfect the root canal and subsequently attract or transplant mesenchymal stem cells from the (remaining) dental pulp and apical papilla (in case of immature permanent teeth) into the root canal. More specifically, this therapy is not based on mechanical and (aggressive) chemical debridement as in conventional root canal treatment but is supported by the pillars of tissue engineering: stem cells, growth factors and a scaffold .

Sponsors & Collaborators

  • University Ghent

    collaborator OTHER

  • University of Erlangen-Nürnberg

    collaborator OTHER

  • University of Regensburg

    collaborator OTHER

  • University of Coimbra

    collaborator OTHER

  • Universitaire Ziekenhuizen KU Leuven

    lead OTHER

Eligibility

Min Age
6 Years
Max Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-01
Primary Completion
2028-09-01
Completion
2030-09-01

Countries

  • Belgium

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06043453 on ClinicalTrials.gov