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Cardiovascular Consequences of Inhaled Short-acting Beta-agonist Use

NCT06027606 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 81

Last updated 2025-11-18

No results posted yet for this study

Summary

The goal of this clinical trial is to test the impact inhalers have on blood vessels in young healthy individuals. The main question it aims to answer is if long term use of asthma inhalers have any effect on the blood vessels and heart. Participants will be asked to:

* Perform lung function and exercise tests
* Have ultrasound images taken of the artery in their arm
* Use an inhaler for 4 weeks
* Visit the lab for testing on 4-6 different occasions

Researchers will compare two different inhalers (Ventolin and Symbicort) with a placebo to see if the inhalers have any effect on the blood vessels over the 4 week period.

Conditions

  • Healthy

Interventions

DRUG

Salbutamol 400mcg

Salbutamol is a short-acting beta-agonist used primarily as a rescue inhaler for respiratory disease such as asthma

DRUG

Budesonide/formoterol

Budesonide/formoterol is a inhaled corticosteroid with long-acting beta-agonist component primarily used as a maintenance inhaler for respiratory conditions such as asthma

DRUG

Placebo

Practice inhaler primarily used in training scenarios so looks identical to medical inhalers

Sponsors & Collaborators

  • University of Alberta

    lead OTHER

Principal Investigators

  • Tracey Bryan, MD · University of Alberta

  • Michael K Stickland, PhD · University of Alberta

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-09-01
Primary Completion
2025-09-25
Completion
2025-09-25

Countries

  • Canada

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06027606 on ClinicalTrials.gov