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Low-intensity Versus Medium-intensity Continuous Kidney Replacement Therapy for Critically Ill Patients

NCT06014801 · Status: RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 400

Last updated 2024-10-15

No results posted yet for this study

Summary

This clinical trial aims to investigate whether the low treatment intensity (12 mL/kg/hr, low-dose hemodialysis/filtration) or the medium treatment intensity (25 mL/kg/hr, standard-dose hemodialysis/filtration) is more effective and safer for continuous renal replacement therapy in critically ill patients.

Conditions

  • Acute Kidney Injury Requiring Continuous Renal Replacement Therapy

Interventions

DRUG

Dialysate fluid, Filtration replacement fluid

Dose of continuous hemodialysis and/or hemofiltration

Sponsors & Collaborators

  • University of Fukui

    collaborator OTHER

  • Tsuchiura Kyodo General Hospital

    collaborator OTHER

  • Keio University

    collaborator OTHER

  • Wakayama Medical University

    collaborator OTHER

  • Jichi Medical University

    collaborator OTHER

  • Sendai Medical Center

    collaborator UNKNOWN

  • Osaka Medical and Pharmaceutical University Hospital

    collaborator UNKNOWN

  • Jikei University School of Medicine

    lead OTHER

Principal Investigators

  • Tomoko Fujii, MD,PhD · Jikei University School of Medicine

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-10-30
Primary Completion
2025-12-31
Completion
2026-09-30

Countries

  • Japan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06014801 on ClinicalTrials.gov