Adaptive Bridging RT in R/R B-cell Lymphoma (Pre-CAR T)
NCT06004167 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2025-12-09
Summary
Participants are invited to take part in this research study because they have relapsed (cancer has come back) or refractory (cancer has not responded to treatment) B-cell Lymphoma and will be undergoing CAR T-cell Therapy.
This research is being done to see if a new radiation therapy administration schedule will positively impact the logistics, time, cost, and side effects of radiation therapy.
In this research study, participants will receive radiation therapy once weekly for 5 weeks. This is a novel administration schedule and we're looking to see how this schedule impacts side effects participants may experience, the time spent receiving radiation therapy, how much radiation therapy participants can receive, and how effective this new schedule is.
Conditions
- Lymphoma, B-Cell
- Relapsed Cancer
- Refractory Lymphoma
- Diffuse Large B Cell Lymphoma
- Mediastinal Large B-cell Lymphoma
- High-grade B-cell Lymphoma
- Follicular Lymphoma
- Mantle Cell Lymphoma
Interventions
- RADIATION
-
Adaptive Bridging Radiation Therapy (ABRT)
Radiation Therapy
Sponsors & Collaborators
-
Varian Medical Systems
collaborator INDUSTRY -
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Chirayu Patel, MD · Massachusetts General Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2024-01-14
- Primary Completion
- 2024-10-01
- Completion
- 2024-12-01
- FDA Device
- Yes
Countries
- United States
Study Locations
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