Trial Outcomes & Findings for Neuromodulation for Comorbid Hoarding Disorder and Depression (NCT NCT05985356)
NCT ID: NCT05985356
Last Updated: 2026-06-17
Results Overview
Saving Inventory - Revised, measuring hoarding symptom severity. Min=0, Max=92. Higher scores indicate more severe hoarding symptoms.
COMPLETED
NA
14 participants
change from baseline to 8 weeks
2026-06-17
Participant Flow
Participants were initially recruited from a waitlist for HD treatment in the San Diego, California area. However, participants also found the study online via clinicaltrials.gov
This was a single group study. Participants completed baseline assessment and then began treatment.
Participant milestones
| Measure |
iTBS
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Overall Study
STARTED
|
11
|
|
Overall Study
COMPLETED
|
10
|
|
Overall Study
NOT COMPLETED
|
1
|
Reasons for withdrawal
| Measure |
iTBS
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Overall Study
Withdrawal by Subject
|
1
|
Baseline Characteristics
3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Baseline characteristics by cohort
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Age, Continuous
|
52 years
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Sex: Female, Male
Female
|
6 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Sex: Female, Male
Male
|
5 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
Asian
|
1 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
Black or African American
|
0 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
White
|
10 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
More than one race
|
0 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
2 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
9 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=9 Participants • 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
|
|
HAM-D
|
22.4 score on a scale
STANDARD_DEVIATION 3.2 • n=9 Participants
|
|
PHQ-9
|
16.6 score on a scale
STANDARD_DEVIATION 5.0 • n=9 Participants
|
|
HRS
|
30.6 score on a scale
STANDARD_DEVIATION 5.3 • n=9 Participants
|
|
SI-R
|
63.7 score on a scale
STANDARD_DEVIATION 9.2 • n=9 Participants
|
|
Resting state functional connectivity
|
-.095 Fisher's Z-score
STANDARD_DEVIATION .057 • n=9 Participants
|
|
Neuropsychological Global Deficit Score
|
.18 Points on a scale
STANDARD_DEVIATION .26 • n=9 Participants
|
PRIMARY outcome
Timeframe: change from baseline to 8 weeksPopulation: 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Saving Inventory - Revised, measuring hoarding symptom severity. Min=0, Max=92. Higher scores indicate more severe hoarding symptoms.
Outcome measures
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Saving Inventory -- Revised
|
50.6 score on a scale
Standard Deviation 16.6
|
PRIMARY outcome
Timeframe: change from baseline to 8 weeksPopulation: 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Hamilton Rating Scale for Depression, measuring depression symptom severity. Min=0, Max=50. Higher scores represent more severe depression symptoms.
Outcome measures
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Hamilton Rating Scale for Depression
|
11.0 score on a scale
Standard Deviation 7.2
|
SECONDARY outcome
Timeframe: change from baseline to 8 weeksPopulation: 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Hoarding Rating Scale, measuring hoarding symptom severity. Min=0, Max=40. Higher scores represent more severe hoarding symptoms.
Outcome measures
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Hoarding Rating Scale
|
11.0 score on a scale
Standard Deviation 7.2
|
SECONDARY outcome
Timeframe: change from baseline to 8 weeksPopulation: 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Patient Health Questionnaire - 9, measuring depression symptom severity. Min=0, Max=27. Higher scores indicate more severe depression symptoms.
Outcome measures
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Patient Health Questionnaire - 9
|
10.4 score on a scale
Standard Deviation 8.5
|
SECONDARY outcome
Timeframe: change from baseline to 8 weeksPopulation: 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Neuropsychological Global Deficit Score, measuring global cognitive performance. Min=0, Max=5. Higher scores indicate worse cognitive performance.
Outcome measures
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Neuropsychological Global Deficit Score
|
.03 Points on a scale
Standard Deviation .06
|
SECONDARY outcome
Timeframe: change from baseline to 4 weeksPopulation: 3 participants not assigned to treatment due to not completing baseline assessment (1) or not meeting study criteria (2)
Resting state functional connectivity between subgenual cingulate and dorsolateral prefrontal cortex. There are no mathematical minimums or maximums for this Fisher's Z score. Higher values represent greater connection between brain regions.
Outcome measures
| Measure |
iTBS
n=11 Participants
intermittent Theta Burst Stimulation (a form of transcranial magnetic stimulation) targeting the left dorsolateral prefrontal cortex
|
|---|---|
|
Resting State Functional Connectivity
|
-.089 Fisher's Z score
Standard Deviation .069
|
Adverse Events
iTBS
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place