A Clinical Study of mRNA Vaccine (ABOR2014/IPM511) in Patients With Advanced Hepatocellular Carcinoma
NCT05981066 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48
Last updated 2023-08-08
Summary
This is an open label, single-site, investigator-initiated trial designed to evaluate the safety, tolerability and preliminary efficacy of ABOR2014(IPM511) injection in relapsed/ refactory HCC.
Conditions
Interventions
- DRUG
-
Neoantigen vaccine, I.M injection
Patients will receive a fixed applicable dose of ABOR2014(IPM511) administered.
Sponsors & Collaborators
-
Peking Union Medical College Hospital
lead OTHER
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SEQUENTIAL
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-07-10
- Primary Completion
- 2024-12-31
- Completion
- 2025-12-31
Countries
- China
Study Locations
More Related Trials
-
Safety and Efficacy of IPM001 in Patients With Advanced Hepatocellular Carcinoma
NCT05536427 ·Status: UNKNOWN ·Phase: PHASE1
-
Immune Checkpoint Inhibitor Monotherapy or Combined With Molecular Targeted Drugs / Locoregional Therapy in the Treatment of Hepatocellular Carcinoma
NCT05609695 ·Status: UNKNOWN
-
Study of Y90-Radioembolization With Nivolumab in Asians With Hepatocellular Carcinoma
NCT03033446 ·Status: COMPLETED ·Phase: PHASE2
-
MB07133 for the Treatment of Patients With Unresectable Hepatocellular Carcinoma
NCT06141096 ·Status: RECRUITING ·Phase: PHASE2
-
A Study to Evaluate SHR-1210 in Subjects With Advanced HCC
NCT02989922 ·Status: COMPLETED ·Phase: PHASE2
-
Lenvatinib Combined Pembrolizumab in Advanced Hepatobiliary Tumors
NCT03895970 ·Status: COMPLETED ·Phase: PHASE2
-
Nimotuzumab Combined With ICIs for the Treatment of Advanced Liver Cancer After First Line Treatment Failure
NCT06413017 ·Status: RECRUITING ·Phase: PHASE2
-
Regorafenib Combined With PD-1 Inhibitor Therapy for Second-line Treatment of Hepatocellular Carcinoma
NCT05048017 ·Status: RECRUITING ·Phase: PHASE2
-
Evaluating the Safety and Efficacy of SB Injection in Patients With Advanced or Primary Hepatocellular Carcinoma (HCC)
NCT01308645 ·Status: UNKNOWN ·Phase: PHASE2
-
Adoptive Autologous iNKT Cells for the Treatment of Progressed Hepatocellular Carcinoma Continuing on PD-1 Inhibitor Therapy
NCT05962450 ·Status: RECRUITING ·Phase: PHASE2
-
Safety and Efficacy Study of Mix Vaccine in Hepatocyte Carcinoma Patient
NCT02338778 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate Safety and Efficacy of Armored CAR-T Cell Injection C-CAR031 in Advanced Hepatocellular Carcinoma
NCT05155189 ·Status: RECRUITING ·Phase: PHASE1
-
Atezolizumab in Combination With a Multi-Kinase Inhibitor for the Treatment of Unresectable, Locally Advanced, or Metastatic Liver Cancer
NCT05168163 ·Status: RECRUITING ·Phase: PHASE2
-
A Study of AK112 in Patients With Advanced Hepatocellular Carcinoma (HCC)
NCT06530251 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
SynOV1.1 Intratumoral Injection Study
NCT04612504 ·Status: UNKNOWN ·Phase: PHASE1
-
PM8002 in Combination With Chemotherapy as First Line Therapy in Hepatocellular Carcinoma
NCT05864105 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Anti-angiogenesis Combined With PD-1/PD-L1 Therapy in Patients With Advanced Liver Cancer
NCT05383066 ·Status: UNKNOWN
-
A Study of Anti-PD-1/CTLA-4 Bispecific AK104 Plus Lenvatinib in First-line Advanced Hepatocellular Carcinoma
NCT04444167 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
A Study of QL1706 in Combination With Bevacizumab and/or Chemotherapy as First-line Treatment in Patients With Advanced Hepatocellular Carcinoma
NCT05976568 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2/PHASE3
-
Clinical Study of Intratumoral Injection of CAR-T Cells in the Treatment of Advanced Liver Tumors
NCT04951141 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Neoantigen Vaccine Plus Capecitabine as Adjuvant Therapy for Intrahepatic Cholangiocarcinoma After Radical Resection
NCT06406816 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
Open Label Trial of Immunotherapy for Advanced Liver Cancer
NCT02256514 ·Status: UNKNOWN ·Phase: PHASE2
-
Efficacy and Safety of Pracytarabine Versus Regorafenib in the Treatment of Patients With Hepatocellular Carcinoma
NCT07300488 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2/PHASE3
-
A Study Combining Personalized Neoantigen-based Dendritic Cell Vaccine With Microwave Ablation for the Treatment of Hepatocellular Carcinoma
NCT03674073 ·Status: UNKNOWN ·Phase: PHASE1
-
QL1706 As Second-line Treatment in Patients with Advanced Hepatocellular Carcinoma
NCT06822985 ·Status: NOT_YET_RECRUITING ·Phase: PHASE1