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CXCL2/CXCL8 Promote Intervertebral Disc Degeneration

NCT05976516 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2023-08-04

No results posted yet for this study

Summary

Low back pain (LBP) is the largest cause of morbidity in the world, and about 80% of Chinese people are affected in their lifetime. Although the prevalence of IDD gradually increases with age, IDD is very common among subjects under 30 years old. In addition to age, there are other factors, such as excessive or uneven mechanical load, obesity, genetics, nutrition, trauma and gender. In addition, it is not clear whether the heavy physical load associated with occupation is an important risk factor for IDD. Some studies have found that IDD is more common among athletes than the general population. Due to the complexity and multifactorial nature of IDD, its pathogenesis and risk factors are still unclear, which seriously hinders the rational stratification of LBP patients and limits the development of personalized treatment.

Conditions

  • Cytokine
  • Intervertebral Disc, Degenerative

Interventions

DIAGNOSTIC_TEST

CXCL2/CXCL8

Detecte CXCL2/8 content in nucleus pulposus and peripheral blood of patients in each group

Sponsors & Collaborators

  • Zhongda Hospital

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-01
Primary Completion
2024-03-30
Completion
2024-03-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05976516 on ClinicalTrials.gov