Effect of Ocrelizumab on Cortical Lesion Accumulation in Patients With PPMS (ORATORIO-Cortical)
NCT05974839 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 732
Last updated 2024-09-26
Summary
The goal of this non-interventional, observational study is to determine whether cortical pathology can be slowed down by use of ocrelizumab.
Conditions
Interventions
- OTHER
-
Ocrelizumab
Non-interventional
Sponsors & Collaborators
-
Genentech, Inc.
collaborator INDUSTRY -
State University of New York at Buffalo
lead OTHER
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-10-01
- Primary Completion
- 2024-02-28
- Completion
- 2024-02-28
Countries
- United States
Study Locations
More Related Trials
-
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
NCT04035005 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Effects of Ocrevus in Relapsing Multiple Sclerosis
NCT04387734 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
A Study of Orelabrutinib in Patients With Secondary Progressive Multiple Sclerosis
NCT07299019 ·Status: RECRUITING ·Phase: PHASE3
-
Prospective Study to Assess Disease Activity and Biomarkers in Minority Participants With Relapsing Multiple Sclerosis (RMS) After Initiation and During Treatment With Ocrelizumab
NCT04377555 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Ocrelizumab on Neuroinflammation in Multiple Sclerosis as Measured by 11C-PBR28 MR-PET Imaging of Microglia Activation
NCT04230174 ·Status: COMPLETED ·Phase: PHASE4
-
A Study to Evaluate Ocrelizumab Treatment in Participants With Progressive Multiple Sclerosis
NCT03523858 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study to Evaluate the Safety of Administering Ocrelizumab Per a Shorter Infusion Protocol in Participants With Primary Progressive Multiple Sclerosis (PPMS) and Relapsing Multiple Sclerosis (RMS)
NCT03606460 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
NCT02861014 ·Status: COMPLETED ·Phase: PHASE3
-
Evaluating the Efficacy and Safety of Transitioning Patients From Natalizumab to Ocrelizumab
NCT03157830 ·Status: COMPLETED
-
Effect of Ocrelizumab on Brain Innate Immune Microglial Cells Activation in MS Using PET-MRI With 18F-DPA714
NCT03691077 ·Status: UNKNOWN ·Phase: PHASE3
-
Study to Explore the Mechanism of Action of Ocrelizumab and B-Cell Biology in Participants With Relapsing Multiple Sclerosis (RMS) or Primary Progressive Multiple Sclerosis (PPMS)
NCT02688985 ·Status: COMPLETED ·Phase: PHASE3
-
IDP-023 g-NK Cells Plus Ocrelizumab in Patients With Progressive Multiple Sclerosis
NCT06677710 ·Status: SUSPENDED ·Phase: PHASE1
-
A Study of Ocrelizumab in Participants With Relapsing Remitting Multiple Sclerosis (RRMS) Who Have Had a Suboptimal Response to an Adequate Course of Disease-Modifying Treatment (DMT)
NCT02637856 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Provide Complementary Efficacy, Safety and Patient Reported Outcomes Data in Participants With Active Relapsing Forms of Multiple Sclerosis (MS) in a Pragmatic Setting
NCT03589105 ·Status: COMPLETED ·Phase: PHASE4
-
A Phase 2 Study of Orelabrutinib in Patients With Relapsing-Remitting Multiple Sclerosis
NCT04711148 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Expanded Access Program for Ocrelizumab in Participants With Primary Progressive Multiple Sclerosis
NCT02807285 ·Status: NO_LONGER_AVAILABLE
-
Ocrelizumab Discontinuation in Relapsing Multiple Sclerosis
NCT05285891 ·Status: RECRUITING ·Phase: PHASE4
-
Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Participants With Early Stage Relapsing Remitting Multiple Sclerosis (RRMS)
NCT03085810 ·Status: TERMINATED ·Phase: PHASE3
-
Symptom Burden in Patients Treated With Ocrelizumab for Multiple Sclerosis
NCT04855617 ·Status: COMPLETED
-
Non-interventional Study of Ocrelizumab in Participants With Relapsing or Primary Progressive Multiple Sclerosis
NCT03593590 ·Status: COMPLETED
-
Ocrelizumab Effects on the Metabolome in MS
NCT03873389 ·Status: COMPLETED
-
Effects of Ocrelizumab on B-cell Tolerance Defect in Relapsing Multiple Sclerosis
NCT04261790 ·Status: COMPLETED ·Phase: PHASE4
-
A Study of the Efficacy and Safety of Ocrelizumab in Patients With Relapsing-Remitting Multiple Sclerosis
NCT00676715 ·Status: COMPLETED ·Phase: PHASE2
-
People With Multiple Sclerosis Treated With Ocrelizumab and GLP-1 Agonists
NCT07207148 ·Status: RECRUITING
-
Ocrelizumab Access by Socio-Economic Status
NCT05131984 ·Status: COMPLETED