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Peer Recovery to Improve Polysubstance Use and Mobile Telemedicine Retention

NCT05973838 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-04-27

No results posted yet for this study

Summary

The purpose of this study is to evaluate the feasibility and effectiveness of a peer-led, brief, behavioral intervention to improve adherence to medication for opioid use disorder (MOUD) and reduce polysubstance use among patients with OUD and polysubstance use in underserved areas. The intervention is based on behavioral activation (BA) and is specifically designed to be implemented by a trained peer recovery specialist. In this hybrid, Type-1 effectiveness-implementation randomized controlled trial (RCT), the investigators will evaluate the effectiveness and implementation of Peer Activate vs. treatment as usual (TAU) over twelve months.

Conditions

  • Polysubstance Addiction
  • Opioid Medication Assisted Treatment
  • Treatment Adherence
  • Retention in Care
  • Substance-Related Disorders

Interventions

BEHAVIORAL

Peer-Delivered Behavioral Activation ("Peer Activate")

The PRS-delivered Peer Activate intervention will consist of approximately six weekly "core" sessions (approximately 30 minutes-1 hour), and then 6 optional "booster" sessions to reinforce skill practice. In Peer Activate sessions, participants will learn behavioral activation and problem-solving skills to reduce barriers to medication nonadherence and incorporate value-driven, substance-free, rewarding activities into their daily life to reduce polysubstance use and improve retention.

Sponsors & Collaborators

  • University of Maryland, Baltimore

    collaborator OTHER

  • Weill Medical College of Cornell University

    collaborator OTHER

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • University of Maryland, College Park

    lead OTHER

Principal Investigators

  • Jessica F Magidson, PhD · University of Maryland, College Park

  • Sarah M Kattakuzhy, MD · University of Maryland, Baltimore

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-15
Primary Completion
2027-07-01
Completion
2027-09-01

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05973838 on ClinicalTrials.gov