Trial Outcomes & Findings for Nicotine and Tobacco Message Framing Among LGBT Young Adults (NCT NCT05972941)
NCT ID: NCT05972941
Last Updated: 2025-06-18
Results Overview
Visual attention measured by dwell time (milliseconds) on areas of interest (AOI; e.g., text, graphic) within a stimuli was assessed via eye-tracking for each message (n=8). Dwell times on AOIs were summed for all stimuli viewed by each participant and averaged. Scores represent total average dwell time on AOIs across stimuli.
COMPLETED
NA
252 participants
During intervention on Day 1, on average 3 minutes
2025-06-18
Participant Flow
Participants who consented to the study but did not complete the activity in REDCap that triggered randomization to an arm, were excluded from the rest of the study.
Participant milestones
| Measure |
Culturally Targeted Messages
Participants will view 8 nicotine and tobacco health messages with lesbian, gay, bisexual, and transgender (LGBT) culturally targeted messages and imagery
|
Non-targeted Messages
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
|
|---|---|---|
|
Overall Study
STARTED
|
129
|
122
|
|
Overall Study
COMPLETED
|
83
|
82
|
|
Overall Study
NOT COMPLETED
|
46
|
40
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Nicotine and Tobacco Message Framing Among LGBT Young Adults
Baseline characteristics by cohort
| Measure |
Culturally Targeted Messages
n=129 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=122 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Total
n=251 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
129 Participants
n=99 Participants
|
122 Participants
n=107 Participants
|
251 Participants
n=206 Participants
|
|
Age, Categorical
>=65 years
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Female
|
61 Participants
n=99 Participants
|
64 Participants
n=107 Participants
|
125 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Male
|
44 Participants
n=99 Participants
|
33 Participants
n=107 Participants
|
77 Participants
n=206 Participants
|
|
Sex/Gender, Customized
Unknown
|
24 Participants
n=99 Participants
|
25 Participants
n=107 Participants
|
49 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Hispanic or Latino
|
4 Participants
n=99 Participants
|
11 Participants
n=107 Participants
|
15 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Not Hispanic or Latino
|
123 Participants
n=99 Participants
|
110 Participants
n=107 Participants
|
233 Participants
n=206 Participants
|
|
Ethnicity (NIH/OMB)
Unknown or Not Reported
|
2 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
3 Participants
n=206 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
1 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Asian
|
17 Participants
n=99 Participants
|
11 Participants
n=107 Participants
|
28 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Black or African American
|
54 Participants
n=99 Participants
|
59 Participants
n=107 Participants
|
113 Participants
n=206 Participants
|
|
Race (NIH/OMB)
White
|
52 Participants
n=99 Participants
|
49 Participants
n=107 Participants
|
101 Participants
n=206 Participants
|
|
Race (NIH/OMB)
More than one race
|
6 Participants
n=99 Participants
|
2 Participants
n=107 Participants
|
8 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Region of Enrollment
United States
|
129 participants
n=99 Participants
|
122 participants
n=107 Participants
|
251 participants
n=206 Participants
|
|
Behavioral Intentions
Subscale 1: Behavioral intentions to avoid cigarettes
|
2.61 units on a scale
STANDARD_DEVIATION 0.81 • n=99 Participants
|
2.49 units on a scale
STANDARD_DEVIATION 0.85 • n=107 Participants
|
2.55 units on a scale
STANDARD_DEVIATION 0.83 • n=206 Participants
|
|
Behavioral Intentions
Subscale 2: Behavioral intentions to avoid nicotine vapes
|
2.29 units on a scale
STANDARD_DEVIATION 0.77 • n=99 Participants
|
2.17 units on a scale
STANDARD_DEVIATION 0.67 • n=107 Participants
|
2.23 units on a scale
STANDARD_DEVIATION 0.72 • n=206 Participants
|
PRIMARY outcome
Timeframe: During intervention on Day 1, on average 3 minutesPopulation: Participants were included for analysis if they completed the eye-tracking experiment and were not missing dwell time data.
Visual attention measured by dwell time (milliseconds) on areas of interest (AOI; e.g., text, graphic) within a stimuli was assessed via eye-tracking for each message (n=8). Dwell times on AOIs were summed for all stimuli viewed by each participant and averaged. Scores represent total average dwell time on AOIs across stimuli.
Outcome measures
| Measure |
Culturally Targeted Messages
n=65 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=71 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Visual Attention - Dwell Time
Textual AOI: Threat
|
1871.00 milliseconds
Interval 1732.95 to 2009.06
|
1881.01 milliseconds
Interval 1763.64 to 1998.38
|
|
Visual Attention - Dwell Time
Textual AOI: Efficacy
|
1695.21 milliseconds
Interval 1570.14 to 1820.27
|
1603.15 milliseconds
Interval 1488.94 to 1717.35
|
|
Visual Attention - Dwell Time
Textual AOI: Quit Resources
|
317.90 milliseconds
Interval 251.71 to 384.09
|
338.23 milliseconds
Interval 278.62 to 397.84
|
|
Visual Attention - Dwell Time
Image AOI: Central Image
|
2771.12 milliseconds
Interval 2612.55 to 2929.69
|
2692.30 milliseconds
Interval 2532.0 to 2852.6
|
|
Visual Attention - Dwell Time
Image AOI: Logo
|
80.75 milliseconds
Interval 52.88 to 108.61
|
97.80 milliseconds
Interval 67.13 to 128.47
|
PRIMARY outcome
Timeframe: During intervention on Day 1, on average 3 minutes.Population: Participants were included for analysis if they completed eye-tracking and did not have missing data capturing time to first fixation.
Time (milliseconds) to first fixation on areas of interest (text, graphic) within a stimuli was assessed via eye-tracking for each message (n=8). Time to first fixation on a specific AOI was summed for all stimuli viewed by each participant and averaged. Scores represent total average time to first fixation on AOIs across stimuli.
Outcome measures
| Measure |
Culturally Targeted Messages
n=65 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=71 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Visual Attention - Time to First Fixation
Textual AOI: Threat
|
890.45 milliseconds
Interval 782.41 to 998.48
|
929.25 milliseconds
Interval 826.81 to 1031.69
|
|
Visual Attention - Time to First Fixation
Textual AOI: Efficacy
|
3525.47 milliseconds
Interval 3320.72 to 3730.23
|
3494.96 milliseconds
Interval 3303.0 to 3686.93
|
|
Visual Attention - Time to First Fixation
Textual AOI: Quit Resources
|
1919.12 milliseconds
Interval 1653.19 to 2185.06
|
1997.02 milliseconds
Interval 1737.94 to 2256.1
|
|
Visual Attention - Time to First Fixation
Image AOI: Central Image
|
1570.31 milliseconds
Interval 1376.93 to 1763.7
|
1520.20 milliseconds
Interval 1323.22 to 1717.18
|
|
Visual Attention - Time to First Fixation
Image AOI: Logo
|
993.50 milliseconds
Interval 775.4 to 1211.6
|
1061.08 milliseconds
Interval 841.73 to 1280.42
|
PRIMARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analytic sample includes all participants for whom baseline and post-exposure data is available.
6-items on a 5-point scale where 1 = Not at all and 5 = Very much. Please rate each statement from 1 (not at all) to 5 (very much). These message are worth remembering. These messages grabbed my attention. These messages are powerful. These messages are convincing. These messages are meaningful. These messages are informative. Individual items are summed and averaged for a total score ranging from 1 to 5. Higher scores indicate a better outcome.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Perceived Message Effectiveness - Message Perceptions
|
3.68 score on a scale
Interval 3.46 to 3.9
|
3.7 score on a scale
Interval 3.5 to 3.92
|
PRIMARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analytic sample includes all participants for whom baseline and post-exposure data is available.
6-items. 5-point scale where 1 = Strongly disagree to 5 = Strongly agree These messages discourage me from smoking cigarettes. These messages make me concerned about the negative effects of smoking cigarettes These messages make smoking cigarettes seem unpleasant to me. 3-items above are summed and averaged. Higher scores indicate better outcome. These messages discourage me from vaping nicotine. These messages make me concerned about the negative effects of vaping nicotine. These messages make vaping nicotine seem unpleasant to me. 3-items above are summed and averaged for a total score ranging from 1 to 5. Higher scores indicate a better outcome.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Perceived Message Effectiveness - Effects Perceptions
Effects Perceptions: Smoking Cigarettes
|
3.64 score on a scale
Interval 3.44 to 3.84
|
3.80 score on a scale
Interval 3.57 to 4.02
|
|
Perceived Message Effectiveness - Effects Perceptions
Effects Perceptions: Vaping Nicotine
|
3.49 score on a scale
Interval 3.27 to 3.72
|
3.69 score on a scale
Interval 3.46 to 3.92
|
PRIMARY outcome
Timeframe: Change from Baseline in behavioral intentions immediately post-exposure to interventionPopulation: Analytic sample includes all participants for whom baseline and post-exposure data is available.
8 items total. 4-point scale 1 = Definitely not to 4 = Definitely will. The following items were asked at baseline and post-exposure. How likely is it that in the next 3 months, you will refrain from vaping nicotine.... * completely and permanently? * when you get lonely? * when you are with your friends who use them? * when someone hands you a vape? How likely is it that in the next 3 months, you will refrain from smoking cigarettes... * completely and permanently? * when you get lonely? * when you are with your friends who use them? * when someone hands you a cigarette? For each subscale, pre-test and post-test items were summed and averaged. Change scores were calculated for each subscale by subtracting pre-test scores from post-test scores. Change scores could range from 0 to 3. Higher change scores indicate a better outcome (i.e. greater change in intentions to refrain from smoking or vaping)
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Change in Behavioral Intentions
Change in cigarette smoking behavioral intentions
|
.20 score on a scale
Interval 0.05 to 0.35
|
.36 score on a scale
Interval 0.21 to 0.51
|
|
Change in Behavioral Intentions
Change in nicotine vaping behavioral intentions
|
.44 score on a scale
Interval 0.28 to 0.61
|
.30 score on a scale
Interval 0.17 to 0.44
|
PRIMARY outcome
Timeframe: Difference between conditions in behavioral intentions to quit smoking at 1-week follow-up after intervention exposurePopulation: Participants who reported current cigarette smoking at 1-week follow-up
Number of participants who answer "Yes" to the following: Do you plan to quit smoking cigarettes in the next 30 days? (Yes/No)
Outcome measures
| Measure |
Culturally Targeted Messages
n=35 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=33 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Behavioral Intentions: Quitting Smoking
|
22 Participants
|
25 Participants
|
PRIMARY outcome
Timeframe: Difference between conditions in behavioral intentions to quit vaping at 1-week follow-up after intervention exposurePopulation: Participants reporting nicotine vaping at follow-up
Number of participants who answer "Yes" to the following: "Do you plan to quit vaping nicotine in the next 30 days?" (Yes/No)
Outcome measures
| Measure |
Culturally Targeted Messages
n=39 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=39 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Behavioral Intentions to Quit Vaping
|
29 Participants
|
31 Participants
|
SECONDARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analysis includes all participants for whom baseline and post-exposure data is available.
3-items; 5-point Likert scale where 1 = Strongly disagree and 5 = Strongly agree These messages are trying to manipulate me. These messages annoy me. The health effects of these messages are overblown. Items are summed and averaged for a total score ranging from 1 to 5. Higher scores indicate a worse outcome.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Reactance
|
2.11 score on a scale
Interval 1.92 to 2.3
|
2.07 score on a scale
Interval 1.86 to 2.29
|
SECONDARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analysis includes all participants for whom baseline and post-exposure data is available.
5 items; 7-point Likert scale where 1 = Strongly Disagree and 7 = Strongly agree These ads were created just for me. These ads were created for people like me. These ads were relevant to me. These ads were of value to me. These ads were important to me. Items were summed and averaged for a total score ranging from 1 to 7. Higher scores indicate a better outcome.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Ad Relevance
|
3.65 score on a scale
Interval 3.39 to 3.91
|
3.64 score on a scale
Interval 3.33 to 3.94
|
SECONDARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analysis includes all participants for whom baseline and post-exposure data is available.
Single item; 5-point Likert scale where 1 = Strongly disagree and 5 = Strongly agree I like these messages.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Liking
|
3.82 score on a scale
Interval 3.61 to 4.03
|
4.04 score on a scale
Interval 3.81 to 4.26
|
SECONDARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analysis includes all participants for whom baseline and post-exposure data is available.
Two items; 7-point Likert scale where 1 = These message made me feel much worse and 7 = These message made me feel much better. Did these messages change how you feel about smoking combustible cigarettes? Did these messages change how you feel about vaping nicotine? Higher scores mean a worse outcome.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Attitudes
Change in feelings about smoking cigarettes
|
2.78 score on a scale
Interval 2.49 to 3.07
|
2.94 score on a scale
Interval 2.63 to 3.25
|
|
Attitudes
Change in feelings about vaping nicotine
|
2.81 score on a scale
Interval 2.52 to 3.09
|
2.90 score on a scale
Interval 2.59 to 3.21
|
SECONDARY outcome
Timeframe: Immediately post-exposure to interventionPopulation: Analysis includes all participants for whom baseline and post-exposure data is available.
6-items; 5 point Likert scale where 1 = Strongly disagree and 5 = Strongly agree These messages will motivate CIGARETTE SMOKERS to switch to vaping. These messages will motivate people to quit ALL smoking and vaping. These messages will motivate NON-USERS to start vaping. These messages will motivate NON-USERS to start smoking cigarettes. These messages will motivate CIGARETTE SMOKERS to quit. These messages will motivate VAPERS to quit. Higher scores mean a better outcome.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Response Efficacy
These messages will motivate VAPERS to quit.
|
3.34 score on a scale
Interval 3.07 to 3.61
|
3.51 score on a scale
Interval 3.26 to 3.76
|
|
Response Efficacy
These messages will motivate NON-USERS to start smoking cigarettes.
|
1.46 score on a scale
Interval 1.26 to 1.66
|
1.38 score on a scale
Interval 1.2 to 1.55
|
|
Response Efficacy
These messages will motivate CIGARETTE SMOKERS to quit.
|
3.41 score on a scale
Interval 3.16 to 3.66
|
3.46 score on a scale
Interval 3.2 to 3.73
|
|
Response Efficacy
These messages will motivate CIGARETTE SMOKERS to switch to vaping.
|
2.07 score on a scale
Interval 1.82 to 2.33
|
1.93 score on a scale
Interval 1.68 to 2.17
|
|
Response Efficacy
These messages will motivate people to quit ALL smoking and vaping.
|
3.48 score on a scale
Interval 3.23 to 3.73
|
3.43 score on a scale
Interval 3.16 to 3.69
|
|
Response Efficacy
These messages will motivate NON-USERS to start vaping.
|
1.53 score on a scale
Interval 1.29 to 1.77
|
1.51 score on a scale
Interval 1.29 to 1.74
|
SECONDARY outcome
Timeframe: 1-week follow-up after intervention exposurePopulation: Number of participants who reported recalling something about the health messages.
Participants will be asked the following question: "The images that you viewed included health messages. What do you remember about the health messages?" Outcome indicates then number of participants who qualitatively reported recalling something about the health message.
Outcome measures
| Measure |
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
|
|---|---|---|
|
Qualitative Recall of Health Messages
|
81 Participants
|
79 Participants
|
Adverse Events
Culturally Targeted Messages
Non-targeted Messages
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Dr. Joanne G. Patterson
The Ohio State University College of Public Health
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place