Trial Outcomes & Findings for Nicotine and Tobacco Message Framing Among LGBT Young Adults (NCT NCT05972941)

NCT ID: NCT05972941

Last Updated: 2025-06-18

Results Overview

Visual attention measured by dwell time (milliseconds) on areas of interest (AOI; e.g., text, graphic) within a stimuli was assessed via eye-tracking for each message (n=8). Dwell times on AOIs were summed for all stimuli viewed by each participant and averaged. Scores represent total average dwell time on AOIs across stimuli.

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

252 participants

Primary outcome timeframe

During intervention on Day 1, on average 3 minutes

Results posted on

2025-06-18

Participant Flow

Participants who consented to the study but did not complete the activity in REDCap that triggered randomization to an arm, were excluded from the rest of the study.

Participant milestones

Participant milestones
Measure
Culturally Targeted Messages
Participants will view 8 nicotine and tobacco health messages with lesbian, gay, bisexual, and transgender (LGBT) culturally targeted messages and imagery
Non-targeted Messages
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery
Overall Study
STARTED
129
122
Overall Study
COMPLETED
83
82
Overall Study
NOT COMPLETED
46
40

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

Nicotine and Tobacco Message Framing Among LGBT Young Adults

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure
Culturally Targeted Messages
n=129 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=122 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Total
n=251 Participants
Total of all reporting groups
Age, Categorical
<=18 years
0 Participants
n=99 Participants
0 Participants
n=107 Participants
0 Participants
n=206 Participants
Age, Categorical
Between 18 and 65 years
129 Participants
n=99 Participants
122 Participants
n=107 Participants
251 Participants
n=206 Participants
Age, Categorical
>=65 years
0 Participants
n=99 Participants
0 Participants
n=107 Participants
0 Participants
n=206 Participants
Sex/Gender, Customized
Female
61 Participants
n=99 Participants
64 Participants
n=107 Participants
125 Participants
n=206 Participants
Sex/Gender, Customized
Male
44 Participants
n=99 Participants
33 Participants
n=107 Participants
77 Participants
n=206 Participants
Sex/Gender, Customized
Unknown
24 Participants
n=99 Participants
25 Participants
n=107 Participants
49 Participants
n=206 Participants
Ethnicity (NIH/OMB)
Hispanic or Latino
4 Participants
n=99 Participants
11 Participants
n=107 Participants
15 Participants
n=206 Participants
Ethnicity (NIH/OMB)
Not Hispanic or Latino
123 Participants
n=99 Participants
110 Participants
n=107 Participants
233 Participants
n=206 Participants
Ethnicity (NIH/OMB)
Unknown or Not Reported
2 Participants
n=99 Participants
1 Participants
n=107 Participants
3 Participants
n=206 Participants
Race (NIH/OMB)
American Indian or Alaska Native
0 Participants
n=99 Participants
1 Participants
n=107 Participants
1 Participants
n=206 Participants
Race (NIH/OMB)
Asian
17 Participants
n=99 Participants
11 Participants
n=107 Participants
28 Participants
n=206 Participants
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
0 Participants
n=99 Participants
0 Participants
n=107 Participants
0 Participants
n=206 Participants
Race (NIH/OMB)
Black or African American
54 Participants
n=99 Participants
59 Participants
n=107 Participants
113 Participants
n=206 Participants
Race (NIH/OMB)
White
52 Participants
n=99 Participants
49 Participants
n=107 Participants
101 Participants
n=206 Participants
Race (NIH/OMB)
More than one race
6 Participants
n=99 Participants
2 Participants
n=107 Participants
8 Participants
n=206 Participants
Race (NIH/OMB)
Unknown or Not Reported
0 Participants
n=99 Participants
0 Participants
n=107 Participants
0 Participants
n=206 Participants
Region of Enrollment
United States
129 participants
n=99 Participants
122 participants
n=107 Participants
251 participants
n=206 Participants
Behavioral Intentions
Subscale 1: Behavioral intentions to avoid cigarettes
2.61 units on a scale
STANDARD_DEVIATION 0.81 • n=99 Participants
2.49 units on a scale
STANDARD_DEVIATION 0.85 • n=107 Participants
2.55 units on a scale
STANDARD_DEVIATION 0.83 • n=206 Participants
Behavioral Intentions
Subscale 2: Behavioral intentions to avoid nicotine vapes
2.29 units on a scale
STANDARD_DEVIATION 0.77 • n=99 Participants
2.17 units on a scale
STANDARD_DEVIATION 0.67 • n=107 Participants
2.23 units on a scale
STANDARD_DEVIATION 0.72 • n=206 Participants

PRIMARY outcome

Timeframe: During intervention on Day 1, on average 3 minutes

Population: Participants were included for analysis if they completed the eye-tracking experiment and were not missing dwell time data.

Visual attention measured by dwell time (milliseconds) on areas of interest (AOI; e.g., text, graphic) within a stimuli was assessed via eye-tracking for each message (n=8). Dwell times on AOIs were summed for all stimuli viewed by each participant and averaged. Scores represent total average dwell time on AOIs across stimuli.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=65 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=71 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Visual Attention - Dwell Time
Textual AOI: Threat
1871.00 milliseconds
Interval 1732.95 to 2009.06
1881.01 milliseconds
Interval 1763.64 to 1998.38
Visual Attention - Dwell Time
Textual AOI: Efficacy
1695.21 milliseconds
Interval 1570.14 to 1820.27
1603.15 milliseconds
Interval 1488.94 to 1717.35
Visual Attention - Dwell Time
Textual AOI: Quit Resources
317.90 milliseconds
Interval 251.71 to 384.09
338.23 milliseconds
Interval 278.62 to 397.84
Visual Attention - Dwell Time
Image AOI: Central Image
2771.12 milliseconds
Interval 2612.55 to 2929.69
2692.30 milliseconds
Interval 2532.0 to 2852.6
Visual Attention - Dwell Time
Image AOI: Logo
80.75 milliseconds
Interval 52.88 to 108.61
97.80 milliseconds
Interval 67.13 to 128.47

PRIMARY outcome

Timeframe: During intervention on Day 1, on average 3 minutes.

Population: Participants were included for analysis if they completed eye-tracking and did not have missing data capturing time to first fixation.

Time (milliseconds) to first fixation on areas of interest (text, graphic) within a stimuli was assessed via eye-tracking for each message (n=8). Time to first fixation on a specific AOI was summed for all stimuli viewed by each participant and averaged. Scores represent total average time to first fixation on AOIs across stimuli.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=65 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=71 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Visual Attention - Time to First Fixation
Textual AOI: Threat
890.45 milliseconds
Interval 782.41 to 998.48
929.25 milliseconds
Interval 826.81 to 1031.69
Visual Attention - Time to First Fixation
Textual AOI: Efficacy
3525.47 milliseconds
Interval 3320.72 to 3730.23
3494.96 milliseconds
Interval 3303.0 to 3686.93
Visual Attention - Time to First Fixation
Textual AOI: Quit Resources
1919.12 milliseconds
Interval 1653.19 to 2185.06
1997.02 milliseconds
Interval 1737.94 to 2256.1
Visual Attention - Time to First Fixation
Image AOI: Central Image
1570.31 milliseconds
Interval 1376.93 to 1763.7
1520.20 milliseconds
Interval 1323.22 to 1717.18
Visual Attention - Time to First Fixation
Image AOI: Logo
993.50 milliseconds
Interval 775.4 to 1211.6
1061.08 milliseconds
Interval 841.73 to 1280.42

PRIMARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analytic sample includes all participants for whom baseline and post-exposure data is available.

6-items on a 5-point scale where 1 = Not at all and 5 = Very much. Please rate each statement from 1 (not at all) to 5 (very much). These message are worth remembering. These messages grabbed my attention. These messages are powerful. These messages are convincing. These messages are meaningful. These messages are informative. Individual items are summed and averaged for a total score ranging from 1 to 5. Higher scores indicate a better outcome.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Perceived Message Effectiveness - Message Perceptions
3.68 score on a scale
Interval 3.46 to 3.9
3.7 score on a scale
Interval 3.5 to 3.92

PRIMARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analytic sample includes all participants for whom baseline and post-exposure data is available.

6-items. 5-point scale where 1 = Strongly disagree to 5 = Strongly agree These messages discourage me from smoking cigarettes. These messages make me concerned about the negative effects of smoking cigarettes These messages make smoking cigarettes seem unpleasant to me. 3-items above are summed and averaged. Higher scores indicate better outcome. These messages discourage me from vaping nicotine. These messages make me concerned about the negative effects of vaping nicotine. These messages make vaping nicotine seem unpleasant to me. 3-items above are summed and averaged for a total score ranging from 1 to 5. Higher scores indicate a better outcome.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Perceived Message Effectiveness - Effects Perceptions
Effects Perceptions: Smoking Cigarettes
3.64 score on a scale
Interval 3.44 to 3.84
3.80 score on a scale
Interval 3.57 to 4.02
Perceived Message Effectiveness - Effects Perceptions
Effects Perceptions: Vaping Nicotine
3.49 score on a scale
Interval 3.27 to 3.72
3.69 score on a scale
Interval 3.46 to 3.92

PRIMARY outcome

Timeframe: Change from Baseline in behavioral intentions immediately post-exposure to intervention

Population: Analytic sample includes all participants for whom baseline and post-exposure data is available.

8 items total. 4-point scale 1 = Definitely not to 4 = Definitely will. The following items were asked at baseline and post-exposure. How likely is it that in the next 3 months, you will refrain from vaping nicotine.... * completely and permanently? * when you get lonely? * when you are with your friends who use them? * when someone hands you a vape? How likely is it that in the next 3 months, you will refrain from smoking cigarettes... * completely and permanently? * when you get lonely? * when you are with your friends who use them? * when someone hands you a cigarette? For each subscale, pre-test and post-test items were summed and averaged. Change scores were calculated for each subscale by subtracting pre-test scores from post-test scores. Change scores could range from 0 to 3. Higher change scores indicate a better outcome (i.e. greater change in intentions to refrain from smoking or vaping)

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Change in Behavioral Intentions
Change in cigarette smoking behavioral intentions
.20 score on a scale
Interval 0.05 to 0.35
.36 score on a scale
Interval 0.21 to 0.51
Change in Behavioral Intentions
Change in nicotine vaping behavioral intentions
.44 score on a scale
Interval 0.28 to 0.61
.30 score on a scale
Interval 0.17 to 0.44

PRIMARY outcome

Timeframe: Difference between conditions in behavioral intentions to quit smoking at 1-week follow-up after intervention exposure

Population: Participants who reported current cigarette smoking at 1-week follow-up

Number of participants who answer "Yes" to the following: Do you plan to quit smoking cigarettes in the next 30 days? (Yes/No)

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=35 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=33 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Behavioral Intentions: Quitting Smoking
22 Participants
25 Participants

PRIMARY outcome

Timeframe: Difference between conditions in behavioral intentions to quit vaping at 1-week follow-up after intervention exposure

Population: Participants reporting nicotine vaping at follow-up

Number of participants who answer "Yes" to the following: "Do you plan to quit vaping nicotine in the next 30 days?" (Yes/No)

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=39 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=39 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Behavioral Intentions to Quit Vaping
29 Participants
31 Participants

SECONDARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analysis includes all participants for whom baseline and post-exposure data is available.

3-items; 5-point Likert scale where 1 = Strongly disagree and 5 = Strongly agree These messages are trying to manipulate me. These messages annoy me. The health effects of these messages are overblown. Items are summed and averaged for a total score ranging from 1 to 5. Higher scores indicate a worse outcome.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Reactance
2.11 score on a scale
Interval 1.92 to 2.3
2.07 score on a scale
Interval 1.86 to 2.29

SECONDARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analysis includes all participants for whom baseline and post-exposure data is available.

5 items; 7-point Likert scale where 1 = Strongly Disagree and 7 = Strongly agree These ads were created just for me. These ads were created for people like me. These ads were relevant to me. These ads were of value to me. These ads were important to me. Items were summed and averaged for a total score ranging from 1 to 7. Higher scores indicate a better outcome.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Ad Relevance
3.65 score on a scale
Interval 3.39 to 3.91
3.64 score on a scale
Interval 3.33 to 3.94

SECONDARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analysis includes all participants for whom baseline and post-exposure data is available.

Single item; 5-point Likert scale where 1 = Strongly disagree and 5 = Strongly agree I like these messages.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Liking
3.82 score on a scale
Interval 3.61 to 4.03
4.04 score on a scale
Interval 3.81 to 4.26

SECONDARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analysis includes all participants for whom baseline and post-exposure data is available.

Two items; 7-point Likert scale where 1 = These message made me feel much worse and 7 = These message made me feel much better. Did these messages change how you feel about smoking combustible cigarettes? Did these messages change how you feel about vaping nicotine? Higher scores mean a worse outcome.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Attitudes
Change in feelings about smoking cigarettes
2.78 score on a scale
Interval 2.49 to 3.07
2.94 score on a scale
Interval 2.63 to 3.25
Attitudes
Change in feelings about vaping nicotine
2.81 score on a scale
Interval 2.52 to 3.09
2.90 score on a scale
Interval 2.59 to 3.21

SECONDARY outcome

Timeframe: Immediately post-exposure to intervention

Population: Analysis includes all participants for whom baseline and post-exposure data is available.

6-items; 5 point Likert scale where 1 = Strongly disagree and 5 = Strongly agree These messages will motivate CIGARETTE SMOKERS to switch to vaping. These messages will motivate people to quit ALL smoking and vaping. These messages will motivate NON-USERS to start vaping. These messages will motivate NON-USERS to start smoking cigarettes. These messages will motivate CIGARETTE SMOKERS to quit. These messages will motivate VAPERS to quit. Higher scores mean a better outcome.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Response Efficacy
These messages will motivate VAPERS to quit.
3.34 score on a scale
Interval 3.07 to 3.61
3.51 score on a scale
Interval 3.26 to 3.76
Response Efficacy
These messages will motivate NON-USERS to start smoking cigarettes.
1.46 score on a scale
Interval 1.26 to 1.66
1.38 score on a scale
Interval 1.2 to 1.55
Response Efficacy
These messages will motivate CIGARETTE SMOKERS to quit.
3.41 score on a scale
Interval 3.16 to 3.66
3.46 score on a scale
Interval 3.2 to 3.73
Response Efficacy
These messages will motivate CIGARETTE SMOKERS to switch to vaping.
2.07 score on a scale
Interval 1.82 to 2.33
1.93 score on a scale
Interval 1.68 to 2.17
Response Efficacy
These messages will motivate people to quit ALL smoking and vaping.
3.48 score on a scale
Interval 3.23 to 3.73
3.43 score on a scale
Interval 3.16 to 3.69
Response Efficacy
These messages will motivate NON-USERS to start vaping.
1.53 score on a scale
Interval 1.29 to 1.77
1.51 score on a scale
Interval 1.29 to 1.74

SECONDARY outcome

Timeframe: 1-week follow-up after intervention exposure

Population: Number of participants who reported recalling something about the health messages.

Participants will be asked the following question: "The images that you viewed included health messages. What do you remember about the health messages?" Outcome indicates then number of participants who qualitatively reported recalling something about the health message.

Outcome measures

Outcome measures
Measure
Culturally Targeted Messages
n=83 Participants
Participants will view 8 nicotine and tobacco health messages with LGBT culturally targeted messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Non-targeted Messages
n=82 Participants
Participants will view 8 nicotine and tobacco health messages with universal messages and imagery Health communications: Participants will view eight culturally targeted or non-targeted health communications about the health risks of nicotine and tobacco use.
Qualitative Recall of Health Messages
81 Participants
79 Participants

Adverse Events

Culturally Targeted Messages

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Non-targeted Messages

Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Dr. Joanne G. Patterson

The Ohio State University College of Public Health

Phone: 614-247-1780

Results disclosure agreements

  • Principal investigator is a sponsor employee
  • Publication restrictions are in place