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Nasal Irrigation With Combination of 0.9% NaCl and Binahong Extract (Anredera Cordifolia) 2,5% In Allergic Rhinitis

NCT05960526 · Status: ENROLLING_BY_INVITATION · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2024-02-28

No results posted yet for this study

Summary

This randomized control trial study aims to know the effects of adding 2,5% Binahong extract on the effectiveness of NaCl 0.9% nasal irrigation in patients with allergic rhinitis. The main questions it aims to answer are:

1. How does the efficacy of Binahong Extract 2,5% with 0,9% NaCl to mRNA expression (IL-4, Il-6, IL-13, and TNF-α)?
2. How does the efficacy of Binahong Extract 2,5% with 0,9% NaCl to clinical symptoms?
3. How does the efficacy of Binahong Extract 2,5% with 0,9% NaCl to quality of life?
4. How does the efficacy of Binahong Extract 2,5% with 0,9% NaCl to physiology? Participants will use nasal irrigation two times daily for two weeks. Researchers will compare the nasal irrigation group using a combination of Binahong Extract 2,5% with the group using NaCl only to see the superior effect.

Conditions

  • Allergic Rhinitis
  • Allergic Rhinitis Due to House Dust Mite

Interventions

DRUG

extract Binahong

Extract Binahong 2.5% as nasal irrigation solution

DRUG

Isotonic saline nasal irrigation

NaCl 0.9% as nasal irrigation solution

Sponsors & Collaborators

  • Gadjah Mada University

    lead OTHER

Principal Investigators

  • Bambang Rianto, MD OHNS · Gadjah Mada University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-06
Primary Completion
2024-09-06
Completion
2024-12-10

Countries

  • Indonesia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05960526 on ClinicalTrials.gov