A Clinical Trial on the Safety and Efficacy of TQB3909 Tablets in Patients With Recurrent or Refractory Chronic Lymphocytic Leukemia (CLL) /Small Lymphocytic Lymphoma (SLL) .
NCT05959694 · Status: RECRUITING · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 107
Last updated 2023-10-23
Summary
This is a phase Ib/II clinical trial to evaluate the safety and efficacy of TQB3909 tablets in patients with recurrent or refractory CLL/SLL.
Conditions
Interventions
- DRUG
-
TQB3909 tablet
TQB3909 is an inhibitor targeting at B-cell lymphoma (BCL)-2 protein.
Sponsors & Collaborators
-
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
lead INDUSTRY
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-10-11
- Primary Completion
- 2025-12-31
- Completion
- 2026-06-30
Countries
- China
Study Locations
More Related Trials
-
CLL-1/CD33 Targeted LCAR-AMDR Cells in Patients With Relapsed or Refractory Acute Myeloid Leukemia
NCT05654779 ·Status: TERMINATED ·Phase: PHASE1
-
A Phase 1 Clinical Trail of NTQ2494 Tablets in Patients With Advanced Hematological Malignancies
NCT06049667 ·Status: RECRUITING ·Phase: PHASE1
-
A Study to Investigate the Efficacy and Safety of MS-553 in CLL/SLL
NCT05272813 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Clinical Trial of TQB3455 Tablets in Patients With Hematological Malignancies
NCT06550713 ·Status: RECRUITING ·Phase: PHASE1
-
The Efficacy and Safety of Nelarabine Injection in Patients With T-lymphoblastic Leukemia and T-lymphoblastic Lymphoma
NCT06434467 ·Status: NOT_YET_RECRUITING ·Phase: PHASE3
-
Efficacy and Safety of Zanubrutinib in Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT03206918 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of TQ-B3525 in Subjects With Relapsed/Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT04808570 ·Status: TERMINATED ·Phase: PHASE1/PHASE2
-
A Study to Evaluate the Safety,PK and PD of APG-2575 in Patients With Hematologic Malignancies
NCT03913949 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE1
-
A Study of SKLB1028 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia
NCT02859948 ·Status: UNKNOWN ·Phase: PHASE1
-
Dose-escalation Study of Oral Administration of S 55746 in Patients With Chronic Lymphocytic Leukaemia and B-Cell Non-Hodgkin Lymphoma
NCT02920697 ·Status: COMPLETED ·Phase: PHASE1
-
Efficacy and Safety Study of SyB L-0501 for Patients With Chronic Lymphocytic Leukemia
NCT02042911 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of Linperlisib in Relapsed/Refractory Large Granular T Lymphocytic Leukemia
NCT06224257 ·Status: RECRUITING ·Phase: PHASE2
-
Cladribine in Combination With GAP in Patients With Refractory/Relapsed Acute Lymphoblastic Leukemia
NCT03318419 ·Status: UNKNOWN ·Phase: PHASE2
-
A Prospective Multicenter Phase 2 Study of FCR/BR Alternating With Ibrutinib in Treatment-naive Patients With CLL
NCT03980002 ·Status: RECRUITING ·Phase: PHASE2
-
Combination of an Anti-PD1 Antibody With Tisagenlecleucel Reinfusion in Children, Adolescents and Young Adults With Acute Lymphoblastic Leukemia After Loss of Persistence
NCT05310591 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
DZD8586 in Patients With Relapsed or Refractory CLL/SLL (TAI-SHAN8)
NCT06539182 ·Status: RECRUITING ·Phase: PHASE2
-
A Phase I, Multicenter, Open-label, Dose-escalation Study to Assess the Safety of Lenalidomide in Patients With Advanced Adult T-cell Leukemia-lymphoma and Peripheral T-cell Lymphomaperipheral T-cell Lymphoma
NCT01169298 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of Oral LBH589 in Adult Patients With Advanced Hematological Malignancies
NCT00621244 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Phase III B in Acute Lymphoblastic Leukemia
NCT03123939 ·Status: COMPLETED ·Phase: PHASE3
-
LILRB4 STAR-T Cells in the Treatment of Relapsed/Refractory Acute Myeloid Leukemia
NCT05518357 ·Status: COMPLETED ·Phase: PHASE1
-
Safety and Tolerability of XmAb®5574 in Chronic Lymphocytic Leukemia
NCT01161511 ·Status: COMPLETED ·Phase: PHASE1
-
Blinatumomab Versus Standard of Care Chemotherapy in Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)
NCT02013167 ·Status: TERMINATED ·Phase: PHASE3
-
A Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Ibrutinib in Participants With Treatment-naive Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
NCT02556892 ·Status: COMPLETED ·Phase: PHASE1
-
Observational Study of CLL/SLL Treatment and Ibrutinib Treatment of CLL/SLL in Routine Clinical Practice
NCT04094051 ·Status: UNKNOWN
-
Efficacy and Safety of LBH589B in Adult Patients With Refractory Chronic Myeloid Leukemia in Accelerated or Blast Phase
NCT00449761 ·Status: TERMINATED ·Phase: PHASE2