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Association Between Biologic Therapy and Demodex Density in Psoriasis Patients: A Comparative Study

NCT05954572 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 34

Last updated 2023-07-20

No results posted yet for this study

Summary

The goal of this observational study is to investigate whether the density of Demodex mites is higher in psoriasis patients treated with biologic agents compared to treatment-naive or topically treated patients. The main question\[s\]it aims to answer are:

* Are Demodex mites higher in psoriasis patients treated with biologic agents?
* In which localization and with what intensity was demodicosis most common?

Participants will be assessed using standardized skin surface biopsy technique in four localization on their face .

Researchers will compare demodex intensity per cm² to see if the biologic treatments effects demodex intensity on psoriasis patients.

Conditions

  • Demodicidosis

Interventions

DIAGNOSTIC_TEST

standardized skin surface biopsy (SSSB)

This technique is applied in four facial localizations, including the forehead, cheeks, and nose. The surface biopsy procedure is performed as follows: one cm² area was marked on a glass slide using a fine ruler. The designated skin area for sampling is gently swabbed with a dry gauze pad to create mild irritation. Subsequently, one drop of cyanoacrylate adhesive is applied to the marked area on the glass slide. The glass slide is carefully pressed onto the skin, allowing the adhesive to adhere. After approximately one minute, the glass slide is gently lifted. The sampled area on the glass slide is examined under x10 and x40 magnification. Immersion oil is applied to enhance visualization and determine the number of Demodex parasites within the marked area. An increased demodicosis is defined as the presence of five or more Demodex parasites per square centimeter of skin.

Sponsors & Collaborators

  • Hasan Aksoy

    lead OTHER

Principal Investigators

  • hasan aksoy · Istanbul Medeniyet University

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-07-14
Primary Completion
2023-08-14
Completion
2023-08-14

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05954572 on ClinicalTrials.gov