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Transmission of Respiratory Viruses in Households in The Gambia: a Longitudinal Cohort Study (TransVIR)

NCT05952336 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 349

Last updated 2023-07-19

No results posted yet for this study

Summary

Primary endpoints

* Incidence of symptomatic and asymptomatic infection with SARS-CoV-2 and other respiratory viruses as determined by molecular (e.g. PCR) and serological testing
* Associations between the magnitude and quality of mucosal and serum antibody responses to SARSCoV- 2 and protection from infection with SARS-CoV-2
* Associations between the magnitude and quality of T cell responses to SARS-CoV-2 and protection from infection with SARS-CoV-2 Secondary endpoints
* Secondary attack rate and household cumulative infection rate with SARS-CoV-2, influenza, RSV, and other respiratory viruses
* Seroincidence and seroprevalence of SARS-CoV-2 a determined by binding antibodies to SARS-CoV-2 spike and nucleocapsid
* Presence of risk factors for symptomatic and asymptomatic infection with respiratory viruses
* Antibody and T cell kinetics of SARS-CoV-2 following infection
* Associations between the magnitude and quality of antibody and T cell responses to seasonal coronaviruses and protection from infection with SARS-CoV-2
* Associations between infection with non-SARS-CoV-2 respiratory viruses and protection from infection with SARS-CoV-2
* Associations between upregulation of gene expression in the mucosa, including interferon stimulated genes (ISGs), and protection from infection with SARS-CoV-2

Conditions

  • Respiratory Viral Infection
  • SARS CoV 2 Infection

Sponsors & Collaborators

  • UK Research and Innovation

    collaborator OTHER

  • Medical Research Council Unit, The Gambia

    lead OTHER

Eligibility

Min Age
12 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-01
Primary Completion
2024-01-31
Completion
2024-01-31

Countries

  • The Gambia

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05952336 on ClinicalTrials.gov