The Osteoarthritis Prevention Study

Summary

The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.

Conditions

• Osteoarthritis, Knee

Interventions

BEHAVIORAL

Diet and Exercise

Group and individual weight loss and weight maintenance sessions combined with exercise throughout the 48 months.

Sponsors & Collaborators

• National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

  collaborator NIH

• Arthritis Foundation

  collaborator OTHER

• National Center for Complementary and Integrative Health (NCCIH)

  collaborator NIH

• Office of Disease Prevention

  collaborator UNKNOWN

• Office of Research on Women's Health (ORWH)

  collaborator NIH

• Office of Behavioral and Social Sciences Research (OBSSR)

  collaborator NIH

• Centers for Disease Control and Prevention

  collaborator FED

• University of Missouri-Columbia

  collaborator OTHER

• Rapid Nutrition PLC

  collaborator UNKNOWN

• Wake Forest University

  lead OTHER

Principal Investigators

• Stephen P Messier, Ph.D. · Wake Forest University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

50 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2024-03-21

Primary Completion

2029-07-31

Completion

2029-07-31

Countries

• United States
• Australia

Study Locations