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Project Khanya: Peer-Delivered Intervention to Improve HIV Medication Adherence and Substance Use in South Africa

NCT05933226 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 160

Last updated 2026-05-07

No results posted yet for this study

Summary

The purpose of this study is to evaluate a stepped care behavioral intervention for HIV medication adherence and substance use ("Khanya") integrated into an HIV primary care setting in South Africa. The intervention is specifically designed to be implemented by non-specialist counselors with lived substance use experience (i.e., peers), using a task sharing, stepped care model in local primary care clinics. The Khanya stepped care package will be compared to usual care, enhanced with referral to a local outpatient substance use treatment program (Enhanced Standard of Care - ESOC) over 12 months.

Conditions

  • Human Immunodeficiency Virus
  • Alcohol-Related Disorders
  • Drug Use
  • Substance Use

Interventions

BEHAVIORAL

Khanya

"Khanya" is a peer-delivered, behavioral intervention to improve HIV medication adherence and reduce problematic SUD symptoms. Participants will either receive Khanya Step 1 or if they continue to struggle with ART adherence, they will be stepped up to the more intensive intervention, Khanya Step 2.

Sponsors & Collaborators

  • University of Cape Town

    collaborator OTHER

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Weill Medical College of Cornell University

    collaborator OTHER

  • University of Miami

    collaborator OTHER

  • University of Maryland, College Park

    lead OTHER

Principal Investigators

  • Jessica F Magidson, MS, PhD · University of Maryland

Study Design

Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-06-21
Primary Completion
2027-02-28
Completion
2027-02-28

Countries

  • South Africa

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05933226 on ClinicalTrials.gov