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Neurophysiologic Biomarkers in Rett Syndrome

NCT05932589 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 202

Last updated 2025-10-20

No results posted yet for this study

Summary

The goal of this observational study is to identify candidate biomarkers in individuals with Rett Syndrome (RTT). The main questions it aims to answer are:

* Do these biomarkers change during clinical changes in individuals with RTT?
* Are biomarkers stable over time in clinically stable individuals?
* Do these biomarkers correlate with severity of RTT?

Participants will be asked to undergo an electroencephalogram (EEG) with measurements of Evoked Potentials (EP) to measure electrical activity in the brain.

Researchers will compare findings in individuals with RTT to those in typically developing individuals to see if there are differences between the two groups.

Conditions

Interventions

OTHER

EEG and Auditory and Visual Evoked Potentials (AEP and VEP)

Through up to eight standardized sessions, participants will undergo AEP and VEP, as well as resting state EEG.

OTHER

Clinical assessment

Established clinical measures for RTT will be collected for RTT participants

Sponsors & Collaborators

  • National Institute of Neurological Disorders and Stroke (NINDS)

    collaborator NIH

  • Vanderbilt University Medical Center

    collaborator OTHER

  • Children's Hospital of Philadelphia

    lead OTHER

Principal Investigators

  • Eric Marsh, MD, PhD · Children's Hospital of Philadelphia

  • Jeffrey Neul, MD, PhD · Vanderbilt University Medical Cener

Eligibility

Min Age
1 Year
Max Age
18 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-10-11
Primary Completion
2028-03-31
Completion
2029-03-31

Countries

  • United States

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05932589 on ClinicalTrials.gov