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Photoprotective Effects of a SPF50+ Sunscreen on Skin Genotoxicity Induced by Repeated Chronic Outdoor Sun Exposure

NCT05926791 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 23

Last updated 2023-07-03

No results posted yet for this study

Summary

Between 2 and 3 million non-melanoma skin cancers and 132,000 melanoma skin cancers occur globally each year. Sun protection continues to be a major public health issue and has always been a priority research area for Pierre Fabre laboratories. The involvement of ultraviolet radiation of the solar spectrum in skin carcinogenesis is well known, through its ability to damage the DNA of skin cells and the induction of oxidative processes.

The aim of this exploratory study is to perform the quantification of:

* DNA photoproducts excised from the genome by the biological repair systems in urine samples
* cellular DNA damage in the epidermis following chronic exposure to natural sunlight.

This study will allow us to better understand and quantify the benefit of sunscreens on photoinduced cellular damage and their elimination in urine.

Conditions

  • Sun Damaged Skin

Interventions

OTHER

Cosmetic product

The educated group receives the cosmetic product SPF50+ according to the randomization list established at V1 and returns the products at V2

Sponsors & Collaborators

  • Pierre Fabre Dermo Cosmetique

    lead INDUSTRY

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-28
Primary Completion
2021-09-13
Completion
2021-09-13

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05926791 on ClinicalTrials.gov