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LISH Trial for the Hepatic Flexure and Proximal Transverse Colon Cancer

NCT05923255 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 568

Last updated 2026-01-27

No results posted yet for this study

Summary

The goal of this clinical trial is to compare the long-term outcomes of Laparoscopic Ileocecal-Sparing Right Hemicolectomy(LISH) compared to traditional laparoscopic right hemicolectomy(TRH) in the treatment of hepatic flexure colon cancer and proximal transverse colon cancer.

Conditions

  • Hepatic Flexure Colon Cancer
  • Proximal Transverse Colon Cancer

Interventions

PROCEDURE

LISH （Laparoscopic Ileocecal-Sparing Right Hemicolectomy）

Preserve the ileocolic blood vessels, and perform dissection of lymph node groups 203, 202, and 201d along the root of ICV(Ileocolic artery)/ICA(Ileocolic vein). Group 201d lymph nodes are defined as the distal lymph nodes of the ileocolic vessels (colonic branch). Use an intracavitary cutting and sealing device to transect the proximal colon along the predetermined margin, and transect the transverse colon at 10cm distal to the tumor. Perform ileocecal-transverse colonic anastomosis.

PROCEDURE

TRH（Traditional Laparoscopic Right Hemicolectomy）

Transect the root of the ileocolic vessels and perform dissection of lymph node groups 203, 202, and 201; sever the roots of the right colic and middle colic vessels, and clear the surrounding lymphoadipose tissue (lymph node groups 211/212/213 and 221/222/223). Transect the transverse colon 10cm distal to the tumor and cut the terminal ileum 10cm from the ileocecal junction. Perform ileum-to-transverse colon anastomosis.

Sponsors & Collaborators

  • Zhejiang University

    lead OTHER

Principal Investigators

  • Kefeng Ding, PhD · Second Affiliated Hospital, School of Medicine, Zhejiang University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-14
Primary Completion
2026-05-14
Completion
2031-05-14

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05923255 on ClinicalTrials.gov