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Effectiveness of Photodynamic Therapy in the Disinfection of Root Canals in Patients With Apical Lesion

NCT05916859 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 159

Last updated 2023-06-23

No results posted yet for this study

Summary

The object of the present study is to compare the effectiveness of conventional endodontic treatment with that of endodontic treatment combined with Photodynamic Therapy (PDT) in patients with apical lesion. Clinical and radiographic examination of the patients will be used to evaluate the presence of apical lesion, size of the lesion, and PAI index. Microbiological examination (evaluation of UFC/ml) will be carried out to assess the disinfection of the root canals. The success rate of the treatment will also be assessed. Endodontic treatment will be carried out in accordance with habitual standards and practices. PDT will be applied with diode laser (660 nm, 100 mW) and methylene blue will be used as photosensitizer (PS). Patients of the Endodontics Service of Universidad San Sebastián (Santiago campus) will be recruited for the study.

Conditions

  • Endodontic Treatment
  • Periapical Diseases

Interventions

OTHER

Group 2 PDT (10 s)

\- Conventional endodontic treatment associated with PDT (10 s)

OTHER

Group 3 PDT 20 s

Conventional endodontic treatment associated with PDAT (20 s)

OTHER

Group 1. Placebo

Conventional endodontic treatment

Sponsors & Collaborators

  • Universidad de La Frontera

    lead OTHER

Principal Investigators

  • Nilton Alves, PhD · Universidad de La Frontera

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2023-12-01
Completion
2024-04-01

Countries

  • Chile

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05916859 on ClinicalTrials.gov