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Combined Respiratory Training in Persons With ALS

NCT05913882 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 34

Last updated 2025-12-23

No results posted yet for this study

Summary

The goal of this interventional trial is to learn about lung volume recruitment (LVR) and expiratory muscle strength training (EMST) in a total of up to 39 patients diagnosed with ALS. The following aims will be addressed:

1. Determine the impact of combined LVR and EMST on cough strength and respiratory function in individuals with ALS.
2. Determine the impact of combined LVR and EMST on patient-reported dyspnea and bulbar impairment.
3. Describe the effect of combined LVR and EMST on patient- and caregiver reported burden and quality of life.

Conditions

Interventions

DEVICE

Respiratory Muscle Strength Training (LVR+EMST)

Combined respiratory muscle strength training regimen that will be completed daily for 5 weeks.

Sponsors & Collaborators

  • Congressionally Directed Medical Research Programs

    collaborator FED

  • Nova Southeastern University

    lead OTHER

Principal Investigators

  • Magalie Thomas, MBA · Nova Southeastern University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-08-22
Primary Completion
2026-09-30
Completion
2026-09-30

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05913882 on ClinicalTrials.gov