State of Oxygen Metabolism, Cardiovascular and Respiratory System Reserve Capacity in Patients Who Underwent COVID-19

Summary

This clinical study will create an evidence base for rehabilitation approach, which will be used for restoration of pulmonary ventilation and gas exchange, increase of tolerance to physical load reduced in patients who underwent COVID-19.

The aim of the present clinical study is to evaluate the effectiveness of medical rehabilitation of COVID-19 patients based on the study of individual physiological parameters of oxygen metabolism and reserve capabilities of the cardiovascular and respiratory systems.

Conditions

• Covid19
• COVID19 Infection

Interventions

DIAGNOSTIC_TEST

Spirography and assessment of pulmonary diffusion capacity

Using the Master Screen Body device you will be asked to take two series of breaths through a special tube for 2-3 minutes. Usually the procedure does not cause any discomfort

DIAGNOSTIC_TEST

Cardiopulmonary stress test

The exercise test is performed on a bicycle ergometer Oxycon Pro. Prior to the test, special sensors for recording the electrocardiogram, a sensor to determine blood saturation, and a cuff to measure blood pressure will be glued on the body. Breathing during the test takes place through a face mask with a built-in gas analyzer sensor. The stress test is conducted up to an individual maximum (according to the age, sex, height and weight of the patient), followed by a recovery period. There is some temporary discomfort associated with performing physical activity. Dyspnea, leg fatigue, and dizziness may occur. Observation continues until full recovery of hemodynamic and gas exchange parameters, in case of appearance of unfavorable symptoms - until their disappearance.

DIAGNOSTIC_TEST

Computed tomography of the chest organs

CT is a method of examination based on X-rays, but unlike conventional X-rays, it gives the most complete picture of the body structure, with less radiation. Tomography usually does not cause any unpleasant feelings and is performed in a specialized department.

DIAGNOSTIC_TEST

Heart echocardiography

It's a specific method of ultrasound examination, which consists in examining the heart in real time and usually does not cause any unpleasant feelings

OTHER

SF-36 Quality of Life Questionnaire

https://clinmedjournals.org/articles/jmdt/jmdt-2-023-figure-1.pdf

DIAGNOSTIC_TEST

Demographic and antropometric measures

Age, sex, height. weight, body mass index (BMI)

OTHER

Indicators characterizing the severity of the underlying disease

* Severity of underlying disease (mMRC, BODE, SMRT-CO Respiratory Support Need Scale), and comorbidities (cardiovascular disease, diabetes mellitus, chronic obstructive pulmonary disease, chronic kidney disease) * Medications taken.

Sponsors & Collaborators

• Meshalkin Research Institute of Pathology of Circulation

  lead NETWORK

Principal Investigators

• Oksana Kamenskaya, PhD, MD · Meshalkin National Research Center

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2020-08-25

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• Russia

Study Locations