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ITreatOCD: Predicting the Efficacy of Internet-based Cognitive Behavioral Therapy in Obsessive-compulsive Disorder

NCT05906069 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2025-01-27

No results posted yet for this study

Summary

In the current study, the investigators will characterize obsessive-compulsive disorder (OCD) patients and healthy controls with a comprehensive clinical and neuroimaging assessment, focusing on the basic psychological processes related and on the neurobiological underpinnings of emotion regulation (ER). After a baseline assessment, the investigators will implement an internet-based cognitive behavioral therapy (iCBT) protocol and assess its efficacy on the modulation of ER and OCD severity. Specifically, the investigators will (1) examine to what extent the iCBT intervention modulates ER and the associated neurobiological mechanisms and (2) identify candidate biomarkers of successful treatment response.

Conditions

  • Obsessive-Compulsive Disorder

Interventions

BEHAVIORAL

ICBT

The intervention will consist in a structured internet-based intervention with 10 modules that will combine cognitive-behavioral techniques to improve obsessive-compulsive symptoms as well as the emotion regulation ability.

Sponsors & Collaborators

  • Hospital de Braga

    collaborator OTHER

  • ICVS - Life and Health Sciences Research Institute

    collaborator UNKNOWN

  • Clinical Academic Center (2CA)

    collaborator UNKNOWN

  • Associação Centro de Medicina P5 (ACMP5)

    collaborator UNKNOWN

  • Pedro Morgado

    lead OTHER

Principal Investigators

  • Pedro Morgado, M.D, Ph.D. · Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-02
Primary Completion
2025-09-30
Completion
2025-12-31

Countries

  • Portugal

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05906069 on ClinicalTrials.gov