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Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories

NCT05902819 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 138

Last updated 2026-03-06

No results posted yet for this study

Summary

An investigation of the effect of matrix-metalloproteinase-(MMP)-9 inhibition with minocycline on the reconsolidation of trauma- or cocaine-related memories

Conditions

  • Post-traumatic Stress Disorder
  • Cocaine Use Disorder

Interventions

BEHAVIORAL

Imagery

Guided imagery of personal trauma- or cocaine-related memory approximately 120min after study medication was given.

DRUG

Minocycline

Single dose of minocycline (200mg) at each of two imagery sessions; Minocycline is given orally in form of a capsule.

DRUG

Placebo

Single dose of mannitol (100%) at each of two imagery sessions; Placebo is given orally in form of a capsule.

Sponsors & Collaborators

  • University of Zurich

    collaborator OTHER

  • Psychiatric University Hospital, Zurich

    lead OTHER

Principal Investigators

  • Boris B. Quednow, Prof. Dr. · Psychiatric University Hospital Zurich, University of Zurich

  • Birgit Kleim, Prof. Dr. · University Hospital of Psychiatry Zurich, University of Zurich

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-05-10
Primary Completion
2026-03-02
Completion
2026-03-02

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05902819 on ClinicalTrials.gov