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Examining the Impact of Transcranial Focused Ultrasound (tFUS) on Reward Neural Circuitry

NCT05875181 · Status: WITHDRAWN · Phase: NA · Type: INTERVENTIONAL

Last updated 2024-12-13

No results posted yet for this study

Summary

The investigators aim to examine the immediate effect of transcranial focused ultrasound (tFUS) on brain activity and emotions in healthy adults as a first stage toward understanding the predisposing brain mechanisms of underlying substance use disorders.

Conditions

  • Impulsive Behavior

Interventions

DEVICE

tFUS

tFUS is a brief stimulation of a part of the brain called the ventral striatum with low-intensity sound waves that pass through the scalp and skull safely.

DEVICE

Sham tFUS

Sham tFUS goes through the motions of applying tFUS to the brain. Participants will know that one session will be a sham, but they will be blinded to which session is the sham

Sponsors & Collaborators

  • Mary Phillips, MD MD (Cantab)

    lead OTHER

Principal Investigators

  • Mary Phillips, MD, MD · University of Pittsburgh

  • Fabio Ferrarelli, MD, PhD · University of Pittsburgh

  • Khaled Moussawi, MD, PhD · University of Pittsburgh

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-06-19
Primary Completion
2024-12-01
Completion
2024-12-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05875181 on ClinicalTrials.gov