Trial Outcomes & Findings for Developing E-liquid Product Standards (Sweet Spot Study) (NCT NCT05864586)
NCT ID: NCT05864586
Last Updated: 2025-04-10
Results Overview
Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.
Recruitment status
COMPLETED
Study phase
NA
Target enrollment
150 participants
Primary outcome timeframe
The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
Results posted on
2025-04-10
Participant Flow
Participant milestones
| Measure |
Young Adult EC Users
Guided by study staff, young adult e-cigarette users and older adult smokers took two puffs from each of the 10 study conditions (\[5%, 25%, 45%, 65%, 85%\] freebase nicotine fractions × \[20 mg/mL, 50 mg/mL\] nicotine concentrations) using the study e-cigarette device. Each condition was administered in a single vaping session, with a 10-minute washout period between conditions. Participants received pre-filled e-liquid pods in random order and were instructed to inhale each puff for at least one second.
|
Older Adult Smokers
Guided by study staff, young adult e-cigarette users and older adult smokers took two puffs from each of the 10 study conditions (\[5%, 25%, 45%, 65%, 85%\] freebase nicotine fractions × \[20 mg/mL, 50 mg/mL\] nicotine concentrations) using the study e-cigarette device. Each condition was administered in a single vaping session, with a 10-minute washout period between conditions. Participants received pre-filled e-liquid pods in random order and were instructed to inhale each puff for at least one second.
|
|---|---|---|
|
Overall Study
STARTED
|
70
|
80
|
|
Overall Study
20mg/mL Nicotine Concentration, 5% Free-base Fraction Study EC Device
|
66
|
67
|
|
Overall Study
20mg/mL Nicotine Concentration, 25% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
20mg/mL Nicotine Concentration, 45% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
20mg/mL Nicotine Concentration, 65% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
20mg/mL Nicotine Concentration, 85% Free-base Fraction Study EC Device
|
66
|
67
|
|
Overall Study
50mg/mL Nicotine Concentration, 5% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
50mg/mL Nicotine Concentration, 25% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
50mg/mL Nicotine Concentration, 45% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
50mg/mL Nicotine Concentration, 65% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
50mg/mL Nicotine Concentration, 85% Free-base Fraction Study EC Device
|
66
|
66
|
|
Overall Study
COMPLETED
|
66
|
66
|
|
Overall Study
NOT COMPLETED
|
4
|
14
|
Reasons for withdrawal
| Measure |
Young Adult EC Users
Guided by study staff, young adult e-cigarette users and older adult smokers took two puffs from each of the 10 study conditions (\[5%, 25%, 45%, 65%, 85%\] freebase nicotine fractions × \[20 mg/mL, 50 mg/mL\] nicotine concentrations) using the study e-cigarette device. Each condition was administered in a single vaping session, with a 10-minute washout period between conditions. Participants received pre-filled e-liquid pods in random order and were instructed to inhale each puff for at least one second.
|
Older Adult Smokers
Guided by study staff, young adult e-cigarette users and older adult smokers took two puffs from each of the 10 study conditions (\[5%, 25%, 45%, 65%, 85%\] freebase nicotine fractions × \[20 mg/mL, 50 mg/mL\] nicotine concentrations) using the study e-cigarette device. Each condition was administered in a single vaping session, with a 10-minute washout period between conditions. Participants received pre-filled e-liquid pods in random order and were instructed to inhale each puff for at least one second.
|
|---|---|---|
|
Overall Study
Ineligible
|
4
|
12
|
|
Overall Study
Pregnancy
|
0
|
1
|
|
Overall Study
Withdrawal by Subject
|
0
|
1
|
Baseline Characteristics
Developing E-liquid Product Standards (Sweet Spot Study)
Baseline characteristics by cohort
| Measure |
Young Adult EC Users
n=66 Participants
Young adult e-cigarette users
|
Older Adult Smokers
n=67 Participants
Older adult cigarette smokers
|
Total
n=133 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Continuous
|
22.12 years
STANDARD_DEVIATION 1.16 • n=99 Participants
|
39.39 years
STANDARD_DEVIATION 6.71 • n=107 Participants
|
30.82 years
STANDARD_DEVIATION 9.91 • n=206 Participants
|
|
Sex: Female, Male
Female
|
51 Participants
n=99 Participants
|
53 Participants
n=107 Participants
|
104 Participants
n=206 Participants
|
|
Sex: Female, Male
Male
|
15 Participants
n=99 Participants
|
14 Participants
n=107 Participants
|
29 Participants
n=206 Participants
|
|
Race (NIH/OMB)
American Indian or Alaska Native
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Asian
|
3 Participants
n=99 Participants
|
1 Participants
n=107 Participants
|
4 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Native Hawaiian or Other Pacific Islander
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Black or African American
|
3 Participants
n=99 Participants
|
9 Participants
n=107 Participants
|
12 Participants
n=206 Participants
|
|
Race (NIH/OMB)
White
|
55 Participants
n=99 Participants
|
54 Participants
n=107 Participants
|
109 Participants
n=206 Participants
|
|
Race (NIH/OMB)
More than one race
|
4 Participants
n=99 Participants
|
3 Participants
n=107 Participants
|
7 Participants
n=206 Participants
|
|
Race (NIH/OMB)
Unknown or Not Reported
|
1 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
1 Participants
n=206 Participants
|
|
Cigarettes Smoked per Day
|
0.02 cigarettes per day
STANDARD_DEVIATION 0.12 • n=99 Participants
|
13.19 cigarettes per day
STANDARD_DEVIATION 6.33 • n=107 Participants
|
6.65 cigarettes per day
STANDARD_DEVIATION 7.99 • n=206 Participants
|
PRIMARY outcome
Timeframe: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.
Outcome measures
| Measure |
Young Adult EC Users - 20mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 5% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 65% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 85% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 5% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 65% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 85% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 85% Free-base fraction
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Behavioral Intentions for Continued Use
Use Product Regularly
|
2.83 score on a scale
Standard Deviation 1.81
|
3.12 score on a scale
Standard Deviation 1.88
|
3.05 score on a scale
Standard Deviation 1.77
|
2.76 score on a scale
Standard Deviation 1.70
|
2.77 score on a scale
Standard Deviation 1.80
|
2.71 score on a scale
Standard Deviation 1.79
|
2.27 score on a scale
Standard Deviation 1.71
|
2.03 score on a scale
Standard Deviation 1.37
|
1.74 score on a scale
Standard Deviation 1.27
|
1.52 score on a scale
Standard Deviation 1.27
|
3.09 score on a scale
Standard Deviation 2.00
|
3.02 score on a scale
Standard Deviation 1.99
|
2.79 score on a scale
Standard Deviation 1.90
|
2.97 score on a scale
Standard Deviation 2.09
|
2.36 score on a scale
Standard Deviation 1.74
|
2.85 score on a scale
Standard Deviation 1.76
|
2.44 score on a scale
Standard Deviation 1.81
|
2.14 score on a scale
Standard Deviation 1.65
|
1.85 score on a scale
Standard Deviation 1.37
|
1.76 score on a scale
Standard Deviation 1.35
|
|
Behavioral Intentions for Continued Use
Try Product Again
|
3.73 score on a scale
Standard Deviation 2.01
|
3.88 score on a scale
Standard Deviation 1.93
|
3.91 score on a scale
Standard Deviation 1.86
|
3.74 score on a scale
Standard Deviation 1.79
|
3.55 score on a scale
Standard Deviation 1.93
|
3.74 score on a scale
Standard Deviation 1.98
|
2.95 score on a scale
Standard Deviation 1.86
|
3.00 score on a scale
Standard Deviation 1.74
|
2.35 score on a scale
Standard Deviation 1.52
|
1.94 score on a scale
Standard Deviation 1.38
|
3.85 score on a scale
Standard Deviation 2.06
|
3.70 score on a scale
Standard Deviation 1.97
|
3.44 score on a scale
Standard Deviation 1.92
|
3.80 score on a scale
Standard Deviation 2.04
|
2.88 score on a scale
Standard Deviation 1.83
|
3.44 score on a scale
Standard Deviation 1.76
|
3.03 score on a scale
Standard Deviation 1.93
|
2.74 score on a scale
Standard Deviation 1.78
|
2.24 score on a scale
Standard Deviation 1.61
|
2.20 score on a scale
Standard Deviation 1.64
|
|
Behavioral Intentions for Continued Use
Purchase Product for Regular Use
|
2.86 score on a scale
Standard Deviation 1.85
|
2.95 score on a scale
Standard Deviation 1.80
|
2.98 score on a scale
Standard Deviation 1.69
|
2.71 score on a scale
Standard Deviation 1.71
|
2.70 score on a scale
Standard Deviation 1.77
|
2.64 score on a scale
Standard Deviation 1.73
|
2.29 score on a scale
Standard Deviation 1.76
|
2.09 score on a scale
Standard Deviation 1.38
|
1.64 score on a scale
Standard Deviation 1.25
|
1.52 score on a scale
Standard Deviation 1.14
|
3.21 score on a scale
Standard Deviation 1.94
|
3.06 score on a scale
Standard Deviation 1.98
|
3.03 score on a scale
Standard Deviation 1.98
|
3.11 score on a scale
Standard Deviation 2.04
|
2.42 score on a scale
Standard Deviation 1.74
|
2.92 score on a scale
Standard Deviation 1.78
|
2.47 score on a scale
Standard Deviation 1.73
|
2.15 score on a scale
Standard Deviation 1.60
|
1.91 score on a scale
Standard Deviation 1.49
|
1.74 score on a scale
Standard Deviation 1.33
|
PRIMARY outcome
Timeframe: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.Population: Participants who provided valid responses to the gLMS items; responses were missing in two instances
5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity.
Outcome measures
| Measure |
Young Adult EC Users - 20mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 5% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 65% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 85% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 5% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 65% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 85% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 85% Free-base fraction
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Intensity of Sensory Attributes
Throat Hit
|
13.05 score on a scale
Standard Deviation 13.09
|
13.03 score on a scale
Standard Deviation 11.66
|
16.17 score on a scale
Standard Deviation 15.00
|
17.53 score on a scale
Standard Deviation 15.83
|
21.29 score on a scale
Standard Deviation 16.80
|
19.39 score on a scale
Standard Deviation 14.46
|
32.97 score on a scale
Standard Deviation 22.04
|
36.20 score on a scale
Standard Deviation 24.04
|
45.77 score on a scale
Standard Deviation 27.57
|
53.39 score on a scale
Standard Deviation 26.26
|
17.07 score on a scale
Standard Deviation 18.12
|
21.64 score on a scale
Standard Deviation 22.48
|
22.92 score on a scale
Standard Deviation 20.61
|
22.03 score on a scale
Standard Deviation 19.99
|
29.51 score on a scale
Standard Deviation 24.68
|
26.82 score on a scale
Standard Deviation 21.12
|
34.73 score on a scale
Standard Deviation 23.18
|
41.21 score on a scale
Standard Deviation 20.75
|
46.15 score on a scale
Standard Deviation 27.85
|
53.74 score on a scale
Standard Deviation 25.87
|
|
Intensity of Sensory Attributes
Sweetness
|
14.36 score on a scale
Standard Deviation 15.12
|
13.32 score on a scale
Standard Deviation 12.41
|
13.61 score on a scale
Standard Deviation 15.89
|
12.39 score on a scale
Standard Deviation 14.18
|
11.58 score on a scale
Standard Deviation 12.08
|
12.59 score on a scale
Standard Deviation 13.75
|
11.27 score on a scale
Standard Deviation 14.62
|
9.32 score on a scale
Standard Deviation 9.58
|
7.20 score on a scale
Standard Deviation 12.65
|
6.15 score on a scale
Standard Deviation 10.36
|
17.60 score on a scale
Standard Deviation 18.23
|
19.29 score on a scale
Standard Deviation 20.34
|
21.92 score on a scale
Standard Deviation 19.89
|
20.29 score on a scale
Standard Deviation 17.41
|
13.82 score on a scale
Standard Deviation 14.36
|
18.44 score on a scale
Standard Deviation 17.53
|
12.74 score on a scale
Standard Deviation 13.77
|
14.33 score on a scale
Standard Deviation 17.41
|
12.21 score on a scale
Standard Deviation 15.75
|
10.65 score on a scale
Standard Deviation 14.50
|
|
Intensity of Sensory Attributes
Bitterness
|
11.50 score on a scale
Standard Deviation 13.32
|
10.67 score on a scale
Standard Deviation 11.18
|
11.68 score on a scale
Standard Deviation 12.35
|
16.02 score on a scale
Standard Deviation 19.25
|
15.27 score on a scale
Standard Deviation 16.17
|
13.80 score on a scale
Standard Deviation 12.33
|
22.35 score on a scale
Standard Deviation 20.55
|
25.26 score on a scale
Standard Deviation 22.19
|
27.58 score on a scale
Standard Deviation 23.64
|
33.41 score on a scale
Standard Deviation 27.26
|
10.19 score on a scale
Standard Deviation 12.35
|
13.39 score on a scale
Standard Deviation 16.61
|
17.09 score on a scale
Standard Deviation 21.37
|
12.68 score on a scale
Standard Deviation 14.76
|
15.73 score on a scale
Standard Deviation 17.58
|
20.70 score on a scale
Standard Deviation 25.12
|
22.11 score on a scale
Standard Deviation 22.27
|
28.48 score on a scale
Standard Deviation 23.89
|
27.88 score on a scale
Standard Deviation 25.39
|
31.55 score on a scale
Standard Deviation 25.81
|
|
Intensity of Sensory Attributes
Smoothness
|
29.82 score on a scale
Standard Deviation 25.14
|
26.21 score on a scale
Standard Deviation 20.86
|
29.73 score on a scale
Standard Deviation 23.68
|
23.12 score on a scale
Standard Deviation 20.00
|
23.71 score on a scale
Standard Deviation 17.35
|
24.74 score on a scale
Standard Deviation 21.30
|
19.20 score on a scale
Standard Deviation 18.60
|
12.02 score on a scale
Standard Deviation 11.86
|
11.09 score on a scale
Standard Deviation 12.19
|
7.59 score on a scale
Standard Deviation 9.33
|
37.04 score on a scale
Standard Deviation 26.57
|
35.79 score on a scale
Standard Deviation 25.53
|
33.38 score on a scale
Standard Deviation 24.49
|
33.74 score on a scale
Standard Deviation 26.38
|
25.22 score on a scale
Standard Deviation 23.31
|
27.06 score on a scale
Standard Deviation 21.31
|
22.52 score on a scale
Standard Deviation 21.38
|
19.44 score on a scale
Standard Deviation 21.90
|
20.74 score on a scale
Standard Deviation 25.11
|
13.92 score on a scale
Standard Deviation 17.78
|
|
Intensity of Sensory Attributes
Harshness
|
12.48 score on a scale
Standard Deviation 13.95
|
13.53 score on a scale
Standard Deviation 14.79
|
13.02 score on a scale
Standard Deviation 13.84
|
15.48 score on a scale
Standard Deviation 19.13
|
18.14 score on a scale
Standard Deviation 18.26
|
16.44 score on a scale
Standard Deviation 14.75
|
28.70 score on a scale
Standard Deviation 21.76
|
40.41 score on a scale
Standard Deviation 25.62
|
44.53 score on a scale
Standard Deviation 27.66
|
53.26 score on a scale
Standard Deviation 29.61
|
14.33 score on a scale
Standard Deviation 17.77
|
18.03 score on a scale
Standard Deviation 21.83
|
18.76 score on a scale
Standard Deviation 22.65
|
18.24 score on a scale
Standard Deviation 19.73
|
27.88 score on a scale
Standard Deviation 27.77
|
27.03 score on a scale
Standard Deviation 24.99
|
36.36 score on a scale
Standard Deviation 27.28
|
42.77 score on a scale
Standard Deviation 24.66
|
47.42 score on a scale
Standard Deviation 29.32
|
52.77 score on a scale
Standard Deviation 29.00
|
PRIMARY outcome
Timeframe: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.Population: Participants who provided valid responses to the LHS item, LHS data was missing in 7 instances
Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking.
Outcome measures
| Measure |
Young Adult EC Users - 20mg/mL, 5% Free-base
n=65 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 5% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 25% Free-base
n=65 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 65% Free-base
n=65 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 85% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 5% Free-base
n=65 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 45% Free-base
n=65 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 65% Free-base
n=65 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 85% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 85% Free-base fraction
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Degree of Liking or Disliking of Sensations
|
8.34 score on a scale
Standard Deviation 31.61
|
5.33 score on a scale
Standard Deviation 33.35
|
11.83 score on a scale
Standard Deviation 29.47
|
5.42 score on a scale
Standard Deviation 25.27
|
0.05 score on a scale
Standard Deviation 28.63
|
6.89 score on a scale
Standard Deviation 31.31
|
-8.82 score on a scale
Standard Deviation 37.66
|
-15.58 score on a scale
Standard Deviation 33.41
|
-30.00 score on a scale
Standard Deviation 34.31
|
-40.92 score on a scale
Standard Deviation 33.84
|
13.94 score on a scale
Standard Deviation 38.88
|
12.85 score on a scale
Standard Deviation 39.92
|
7.98 score on a scale
Standard Deviation 39.40
|
11.74 score on a scale
Standard Deviation 40.03
|
-7.30 score on a scale
Standard Deviation 40.18
|
1.88 score on a scale
Standard Deviation 40.00
|
-9.27 score on a scale
Standard Deviation 46.73
|
-19.18 score on a scale
Standard Deviation 41.19
|
-27.18 score on a scale
Standard Deviation 41.80
|
-36.61 score on a scale
Standard Deviation 41.33
|
SECONDARY outcome
Timeframe: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.12-item modified Cigarette Evaluation Questionnaire (mCEQ) completed following e-cigarette self-administration to assess subjective responses to the e-cigarettes. The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Scores for each subscale are calculated as the mean of the individual item responses or the single item. Higher scores indicate greater intensity on that scale.
Outcome measures
| Measure |
Young Adult EC Users - 20mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 20mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 5% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 25% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 45% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 65% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Young Adult EC Users - 50mg/mL, 85% Free-base
n=66 Participants
Young Adult EC Users - 50mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 5% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 65% Free-base
n=66 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 20mg/mL, 85% Free-base
n=67 Participants
Older Adult Smokers - 20mg/mL nicotine concentration, 85% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 5% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 5% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 25% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 25% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 45% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 45% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 65% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 65% Free-base fraction
|
Older Adult Smokers - 50mg/mL, 85% Free-base
n=66 Participants
Older Adult Smokers - 50mg/mL nicotine concentration, 85% Free-base fraction
|
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Subjective Appeal
Satisfaction
|
3.19 score on a scale
Standard Deviation 1.63
|
3.21 score on a scale
Standard Deviation 1.27
|
3.20 score on a scale
Standard Deviation 1.32
|
3.09 score on a scale
Standard Deviation 1.23
|
2.88 score on a scale
Standard Deviation 1.32
|
3.13 score on a scale
Standard Deviation 1.39
|
2.53 score on a scale
Standard Deviation 1.30
|
2.36 score on a scale
Standard Deviation 1.24
|
1.92 score on a scale
Standard Deviation 1.01
|
1.57 score on a scale
Standard Deviation 0.74
|
3.48 score on a scale
Standard Deviation 1.68
|
3.38 score on a scale
Standard Deviation 1.77
|
3.26 score on a scale
Standard Deviation 1.61
|
3.40 score on a scale
Standard Deviation 1.67
|
2.75 score on a scale
Standard Deviation 1.64
|
3.16 score on a scale
Standard Deviation 1.47
|
2.71 score on a scale
Standard Deviation 1.48
|
2.34 score on a scale
Standard Deviation 1.52
|
2.12 score on a scale
Standard Deviation 1.32
|
1.96 score on a scale
Standard Deviation 1.31
|
|
Subjective Appeal
Psychological Reward
|
2.06 score on a scale
Standard Deviation 1.07
|
2.19 score on a scale
Standard Deviation 1.08
|
2.27 score on a scale
Standard Deviation 1.10
|
2.22 score on a scale
Standard Deviation 1.11
|
2.22 score on a scale
Standard Deviation 1.16
|
2.30 score on a scale
Standard Deviation 1.18
|
2.18 score on a scale
Standard Deviation 1.07
|
2.09 score on a scale
Standard Deviation 0.99
|
2.12 score on a scale
Standard Deviation 1.07
|
1.85 score on a scale
Standard Deviation 0.72
|
2.30 score on a scale
Standard Deviation 1.32
|
2.37 score on a scale
Standard Deviation 1.38
|
2.22 score on a scale
Standard Deviation 1.09
|
2.38 score on a scale
Standard Deviation 1.28
|
2.00 score on a scale
Standard Deviation 1.10
|
2.20 score on a scale
Standard Deviation 1.12
|
2.10 score on a scale
Standard Deviation 1.05
|
1.97 score on a scale
Standard Deviation 1.15
|
1.76 score on a scale
Standard Deviation 0.83
|
1.93 score on a scale
Standard Deviation 1.09
|
|
Subjective Appeal
Aversion
|
1.30 score on a scale
Standard Deviation 0.48
|
1.27 score on a scale
Standard Deviation 0.45
|
1.33 score on a scale
Standard Deviation 0.55
|
1.27 score on a scale
Standard Deviation 0.60
|
1.31 score on a scale
Standard Deviation 0.65
|
1.58 score on a scale
Standard Deviation 0.88
|
1.53 score on a scale
Standard Deviation 0.74
|
1.56 score on a scale
Standard Deviation 0.76
|
1.59 score on a scale
Standard Deviation 0.80
|
1.68 score on a scale
Standard Deviation 0.93
|
1.28 score on a scale
Standard Deviation 0.57
|
1.33 score on a scale
Standard Deviation 0.70
|
1.33 score on a scale
Standard Deviation 0.65
|
1.22 score on a scale
Standard Deviation 0.53
|
1.43 score on a scale
Standard Deviation 0.84
|
1.48 score on a scale
Standard Deviation 0.82
|
1.33 score on a scale
Standard Deviation 0.71
|
1.42 score on a scale
Standard Deviation 0.75
|
1.55 score on a scale
Standard Deviation 0.92
|
1.48 score on a scale
Standard Deviation 0.80
|
|
Subjective Appeal
Enjoyment of Respiratory Tract Sensations
|
2.88 score on a scale
Standard Deviation 1.55
|
3.15 score on a scale
Standard Deviation 1.38
|
3.03 score on a scale
Standard Deviation 1.38
|
2.88 score on a scale
Standard Deviation 1.27
|
2.85 score on a scale
Standard Deviation 1.32
|
2.98 score on a scale
Standard Deviation 1.39
|
2.52 score on a scale
Standard Deviation 1.45
|
2.30 score on a scale
Standard Deviation 1.29
|
1.95 score on a scale
Standard Deviation 1.26
|
1.56 score on a scale
Standard Deviation 0.98
|
3.31 score on a scale
Standard Deviation 1.72
|
3.30 score on a scale
Standard Deviation 1.87
|
3.14 score on a scale
Standard Deviation 1.73
|
3.26 score on a scale
Standard Deviation 1.77
|
2.58 score on a scale
Standard Deviation 1.64
|
3.17 score on a scale
Standard Deviation 1.71
|
2.62 score on a scale
Standard Deviation 1.54
|
2.03 score on a scale
Standard Deviation 1.58
|
2.00 score on a scale
Standard Deviation 1.39
|
1.86 score on a scale
Standard Deviation 1.37
|
|
Subjective Appeal
Craving Reduction
|
2.23 score on a scale
Standard Deviation 1.49
|
2.53 score on a scale
Standard Deviation 1.61
|
2.68 score on a scale
Standard Deviation 1.65
|
2.50 score on a scale
Standard Deviation 1.65
|
2.70 score on a scale
Standard Deviation 1.61
|
2.92 score on a scale
Standard Deviation 1.71
|
2.67 score on a scale
Standard Deviation 1.66
|
2.42 score on a scale
Standard Deviation 1.55
|
2.26 score on a scale
Standard Deviation 1.46
|
2.21 score on a scale
Standard Deviation 1.60
|
2.78 score on a scale
Standard Deviation 1.54
|
2.91 score on a scale
Standard Deviation 1.71
|
2.76 score on a scale
Standard Deviation 1.55
|
3.02 score on a scale
Standard Deviation 1.53
|
2.67 score on a scale
Standard Deviation 1.54
|
3.00 score on a scale
Standard Deviation 1.44
|
2.65 score on a scale
Standard Deviation 1.55
|
2.44 score on a scale
Standard Deviation 1.51
|
2.26 score on a scale
Standard Deviation 1.38
|
2.32 score on a scale
Standard Deviation 1.37
|
Adverse Events
Young Adult EC Users
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Older Adult Smokers
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place