A Study to Evaluate the Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
NCT05851443 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 240
Last updated 2026-04-14
Summary
The study is being conducted to evaluate the effect of 3 dosing regimens of povorcitinib on pulmonary function
Conditions
- Moderate to Severe Asthma
Interventions
- DRUG
-
povorcitinib
povorcitinib
- OTHER
-
placebo
placebo
- DRUG
-
ICS-LABA
Background Therapy
Sponsors & Collaborators
- lead INDUSTRY
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Max Age
- 65 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2023-07-11
- Primary Completion
- 2026-06-15
- Completion
- 2027-01-31
- FDA Drug
- Yes
Countries
- United States
- Argentina
- Canada
- Germany
- Japan
- Poland
- Spain
Study Locations
More Related Trials
-
Bosentan for Poorly Controlled Asthma
NCT00815347 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Lebrikizumab in Participants With Uncontrolled Asthma on Inhaled Corticosteroids and a Second Controller Medication
NCT01868061 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Itolizumab (EQ001) to Evaluate the Safety, Tolerability, PK, PD, and Clinical Activity in Uncontrolled Asthma
NCT04007198 ·Status: COMPLETED ·Phase: PHASE1
-
A Study of the Safety and Effectiveness of JNJ-39758979 in the Treatment of Adults With Persistent Asthma
NCT00946569 ·Status: COMPLETED ·Phase: PHASE2
-
Evaluation of Dupilumab in Patients With Severe Steroid Dependent Asthma
NCT02528214 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Lebrikizumab (MILR1444A) in Adult Patients With Asthma Who Are Inadequately Controlled on Inhaled Corticosteroids
NCT00930163 ·Status: COMPLETED ·Phase: PHASE2
-
Comparison Of Molecular Targets In Mild To Severe Asthmatics And Healthy Subjects
NCT00331058 ·Status: TERMINATED ·Phase: PHASE1
-
Phase 2a Study to Assess the Efficacy and Safety of AZD4604 in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA
NCT06020014 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of RO5036505 in Patients With Moderate to Severe Asthma
NCT00967590 ·Status: WITHDRAWN ·Phase: PHASE2
-
Inhaled Steroid Treatment as Regular Therapy in Early Asthma
NCT00641914 ·Status: COMPLETED ·Phase: PHASE4
-
An Evaluation Of PF-03715455 In Moderate To Severe Uncontrolled Asthma
NCT02219048 ·Status: TERMINATED ·Phase: PHASE2
-
A Study of Lebrikizumab in Patients Whose Asthma is Uncontrolled With Inhaled Corticosteroids and A Second Controller Medication (LUTE)
NCT01545440 ·Status: COMPLETED ·Phase: PHASE2
-
Single Doses GSK159797 On Patient Safety And Lung Function In Patients With Mild To Moderate Asthma
NCT00354666 ·Status: COMPLETED ·Phase: PHASE2
-
A Study of Lebrikizumab in Patients With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and A Second Controller Medication (VERSE)
NCT01545453 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase 1, Randomized, Double-blind, Placebo-controlled Study Evaluating AMG 691 in Healthy Participants and Participants With Mild-to-Moderate Asthma
NCT06637371 ·Status: RECRUITING ·Phase: PHASE1
-
A Study Evaluating the Efficacy and Safety of Lebrikizumab in Adult Patients With Mild to Moderate Asthma
NCT02104674 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Adult Patients With Asthma
NCT04203797 ·Status: COMPLETED ·Phase: PHASE4
-
A Study of Lebrikizumab in Adolescent Participants With Uncontrolled Asthma Who Are on Inhaled Corticosteroids and a Second Controller Medication
NCT01875003 ·Status: COMPLETED ·Phase: PHASE3
-
Masitinib in Treatment of Patients With Severe Persistent Asthma Treated With Oral Corticosteroids
NCT01449162 ·Status: COMPLETED ·Phase: PHASE3
-
A Randomized Study To Evaluate The Efficacy And Safety Of An Investigational Drug In Adolescent And Adult Subjects With Asthma Uncontrolled on Moderate-Dose ICS Therapy.
NCT00603746 ·Status: COMPLETED ·Phase: PHASE2
-
A Phase II Study to Evaluate the Efficacy, Safety and Tolerability of AZD5069 in Patients With Uncontrolled Persistent Asthma.
NCT01704495 ·Status: COMPLETED ·Phase: PHASE2
-
Study to Evaluate the Safety and Efficacy TPI ASM8 in Subjects With Asthma
NCT00550797 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety Study of GSK679586 in Patients With Severe Asthma
NCT00843193 ·Status: COMPLETED ·Phase: PHASE2
-
Study of Efficacy and Safety of QAW039 in Patients With Severe Asthma Inadequately Controlled With Standard of Care Asthma Treatment.
NCT02555683 ·Status: COMPLETED ·Phase: PHASE3
-
The Safety and Tolerability of GW805858 in Healthy Volunteers and Mild Asthmatics
NCT00453791 ·Status: TERMINATED ·Phase: PHASE1