Trial Outcomes & Findings for High-Intensity Interval Training to Improve Symptoms of Deployment-Related Respiratory Disease (NCT NCT05849168)

Results Overview

Obtained via metabolic cart during maximal cardiopulmonary exercise testing, in ml/kg/min

Recruitment status

COMPLETED

Study phase

NA

Target enrollment

12 participants

Primary outcome timeframe

Up to 1 hour

Results posted on

2026-01-29

Participant Flow

Participant milestones

Participant milestones
Measure	Veterans With Respiratory Symptoms Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Overall Study STARTED	12
Overall Study COMPLETED	11
Overall Study NOT COMPLETED	1

Reasons for withdrawal

Withdrawal data not reported

Baseline Characteristics

High-Intensity Interval Training to Improve Symptoms of Deployment-Related Respiratory Disease

Baseline characteristics by cohort

Baseline characteristics by cohort
Measure	Veterans With Respiratory Symptoms n=12 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Age, Continuous	46 Years STANDARD_DEVIATION 11 • n=41 Participants
Sex: Female, Male Female	0 Participants n=41 Participants
Sex: Female, Male Male	12 Participants n=41 Participants
Race (NIH/OMB) American Indian or Alaska Native	1 Participants n=41 Participants
Race (NIH/OMB) Asian	1 Participants n=41 Participants
Race (NIH/OMB) Native Hawaiian or Other Pacific Islander	0 Participants n=41 Participants
Race (NIH/OMB) Black or African American	2 Participants n=41 Participants
Race (NIH/OMB) White	7 Participants n=41 Participants
Race (NIH/OMB) More than one race	0 Participants n=41 Participants
Race (NIH/OMB) Unknown or Not Reported	1 Participants n=41 Participants
Ethnicity (NIH/OMB) Hispanic or Latino	1 Participants n=41 Participants
Ethnicity (NIH/OMB) Not Hispanic or Latino	11 Participants n=41 Participants
Ethnicity (NIH/OMB) Unknown or Not Reported	0 Participants n=41 Participants

PRIMARY outcome

Timeframe: Up to 1 hour

Obtained via metabolic cart during maximal cardiopulmonary exercise testing, in ml/kg/min

Outcome measures

Outcome measures
Measure	Veterans With Respiratory Symptoms n=12 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Maximum Oxygen Consumption (VO2max)	26.4 ml/kg/min Interval 23.8 to 28.9

PRIMARY outcome

Timeframe: Up to 1 hour

Units, Range 0-100 with higher scores indicating more favorable health state

Outcome measures

Outcome measures
Measure	Veterans With Respiratory Symptoms n=12 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Health-related Quality of Life by Short Form 36 (SF-36) Questionnaire	67 Units on a scale, Range 0-100 Interval 44.0 to 79.0

SECONDARY outcome

Timeframe: Up to 1 hour

Population: Two participants were unable to complete transthoracic echocardiography due to scheduling constraints

%

Outcome measures

Outcome measures
Measure	Veterans With Respiratory Symptoms n=10 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Left Ventricular Ejection Fraction Measured by Transthoracic Echocardiogram	60 % of blood Interval 58.0 to 63.0

SECONDARY outcome

Timeframe: Up to 1 hour

Population: Two participants were unable to complete transthoracic echocardiography due to scheduling constraints

mm

Outcome measures

Outcome measures
Measure	Veterans With Respiratory Symptoms n=10 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Tricuspid Annular Plane Systolic Excursion Measured by Transthoracic Echocardiogram	26 mm Interval 21.0 to 29.0

SECONDARY outcome

Timeframe: Up to 1 hour

Relative ion count

Outcome measures

Outcome measures
Measure	Veterans With Respiratory Symptoms n=12 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Plasma Acylcarnitine 10:0 Measured by Peripheral Venous Metabolomics (Ultra-high Performance Liquid Chromatography Coupled to Mass Spectrometry)	4448588 Relative ion count Interval 3488443.0 to 7035835.0

SECONDARY outcome

Timeframe: Up to 1 hour

Population: One participant withdrew from study

Score, Likert scale indicating agreement with the statement "I was able to complete the scheduled high-intensity interval training sessions," 5-point range from 1 = "Strongly disagree" to 5 = "Strongly agree" with "Strongly agree" indicating greater agreement

Outcome measures

Outcome measures
Measure	Veterans With Respiratory Symptoms n=11 Participants Veterans with respiratory symptoms meeting the inclusion and exclusion criteria
Feasibility of Exercise Program, Reported by Participant and Measured by Responses to Questionnaire	5 Scores on a Likert scale, 5-point range Interval 4.0 to 5.0

Adverse Events

Veterans With Respiratory Symptoms

Serious events: 0 serious events

Other events: 0 other events

Deaths: 0 deaths

Serious adverse events

Adverse event data not reported

Other adverse events

Adverse event data not reported

Additional Information

Lindsay Forbes

University of Colorado

Phone: 303-724-4020

Email: [email protected]

Results disclosure agreements

Principal investigator is a sponsor employee
Publication restrictions are in place