Targeting Beta Cell Dysfunction With Verapamil in Longstanding T1D
NCT05847413 · Status: COMPLETED · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 10
Last updated 2023-05-06
Summary
The purpose of this study is to determine whether verapamil can transiently improve beta cell function in those who do or do not secrete proinsulin and little/no C-peptide.
Conditions
Interventions
- DRUG
-
Verapamil
Subjects will receive oral verapamil for 12 weeks
Sponsors & Collaborators
-
Benaroya Research Institute
lead OTHER
Principal Investigators
-
Carla Greenbaum, MD · Benaroya Research Institute
Study Design
- Allocation
- NA
- Purpose
- BASIC_SCIENCE
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 50 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2020-05-30
- Primary Completion
- 2021-12-10
- Completion
- 2021-12-10
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
The Effects of Neprilysin on Glucagon-like Peptide-1
NCT03717688 ·Status: COMPLETED ·Phase: PHASE4
-
GLP-1 Receptor Targeting in Diabetic and Healthy Individuals
NCT01825148 ·Status: COMPLETED
-
Characterization of Beta Cell Failure
NCT00869102 ·Status: WITHDRAWN ·Phase: NA
-
Liraglutide Effect on Beta-cell Function in C-peptide Positive Type 1 Diabetes
NCT02617654 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy Study of Glucagonlike Peptide-1 to Treat Reperfusion Injury
NCT02001363 ·Status: UNKNOWN ·Phase: NA
-
GLP-1: Acute Effects on Kidney Function in Healthy Men
NCT01333163 ·Status: COMPLETED ·Phase: NA
-
Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes
NCT05478707 ·Status: SUSPENDED ·Phase: PHASE2
-
GLP-1 REceptor Agonists and Real World EvIdeNce
NCT03959865 ·Status: UNKNOWN
-
Cardiovascular Outcomes and HbA1c Among Patients With Type 2 Diabetes Newly Initiating GLP1RAs vs Basal Insulin
NCT04034524 ·Status: UNKNOWN
-
Liraglutide in Newly Onset Type 1 Diabetes.
NCT01879917 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Vasodilatory and Metabolic Effects of Glucagon-like Peptide-1 in Periphery Circulation in Patients With and Without Type 2 Diabetes Mellitus
NCT01689051 ·Status: COMPLETED ·Phase: NA
-
Effect of Intact GLP-1 (7-36) and GLP-1 Metabolite (9-36) on Coronary and Peripheral Vascular Function in Adults
NCT02333591 ·Status: COMPLETED ·Phase: PHASE4
-
β-cell Function in Type 1 Diabetes May Not Be As Low As Presumed
NCT02199470 ·Status: COMPLETED
-
Treatment of Latent Autoimmune Diabetes of the Adult
NCT01140438 ·Status: COMPLETED ·Phase: NA
-
Glucagon-like Peptide-1 and Coronary Microvascular Dysfunction in Women With Angina Pectoris and no Coronary Stenosis
NCT02602600 ·Status: COMPLETED ·Phase: PHASE4
-
Glucagon and Advanced HCL System to Prevent Exercise-Induced Hypoglycaemia in People With Type 1 Diabetes
NCT05379686 ·Status: COMPLETED ·Phase: NA
-
The Effect of the GLP-1 Analogue Exenatide on Type 2 Diabetes in CNS and Heart During Hyperglycemia Assessed by PET
NCT00747968 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Cardiovascular Effects of Rapidly Declining Plasma Glucose in Patients With Type 1 Diabetes
NCT04800536 ·Status: COMPLETED ·Phase: NA
-
Glucagon Counterregulation in Type 1 Diabetes
NCT03547427 ·Status: TERMINATED ·Phase: NA
-
Effect of GLP-1 and GIP on Insulin Secretion in Type-1 Diabetes Mellitus
NCT00603031 ·Status: COMPLETED ·Phase: NA
-
Effect of Liraglutide on Diastolic Dysfunction on Cardiac MRI in Type 2 Diabetes Patients
NCT02655770 ·Status: COMPLETED ·Phase: PHASE4
-
GLP-1 Signaling in Truncally Vagotomized Subjects
NCT02940184 ·Status: UNKNOWN ·Phase: NA
-
Carvedilol in Treating Hypoglycemia Unawareness
NCT03538015 ·Status: TERMINATED ·Phase: PHASE2
-
The Ameliorative Effects of GLP-1RA on Diabetic Cardiac Autonomatic Neuropathy
NCT06461377 ·Status: RECRUITING ·Phase: PHASE4
-
Effects of GLP1-RA on Ectopic Fat Deposition in Chronic Kidney Disease
NCT05254418 ·Status: COMPLETED ·Phase: PHASE2