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Neurocognitive Abnormalities in Stimulant Abuse Among High-Risk Women

NCT05845333 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 334

Last updated 2025-05-08

No results posted yet for this study

Summary

Substance use disorders and psychopathy are serious and costly mental health issues. Psychopathy is known to be associated with aberrant moral decision making and there is considerable interest in determining whether substance use disorders lead to impairments in these same cognitive processes. Recent large-scale research initiatives in forensic settings have begun to identify substance abuse and psychopathy-related disruption in the neural mechanisms involved in moral decision-making processes, and associations between these neural networks and future relapse and antisocial behavior. Here the investigators extend prior work (with incarcerated men) to examine these issues among incarcerated women in order to better understand sex differences. This project addresses the overall lack of neurocognitive research in criminal offenders with substance use disorders, thereby focusing on a major public health issue in an underserved and understudied population.

Conditions

  • Stimulant Abuse
  • Criminal Behavior

Interventions

OTHER

Decision task

Participants will complete a simple and/or moral decision making functional MRI task.

Sponsors & Collaborators

  • The Mind Research Network

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-08-01
Primary Completion
2027-05-31
Completion
2027-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05845333 on ClinicalTrials.gov