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Low-intensity Focused Ultrasound and Autonomic Response

NCT05834829 · Status: ENROLLING_BY_INVITATION · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80

Last updated 2025-06-06

No results posted yet for this study

Summary

Studying the effects of Low Intensity Focused Ultrasound (LIFU) to the dorsal posterior insula (dPI) and dorsal anterior cingulate cortex (dACC) on autonomic control using a test to probe the autonomic system. A cold pressor task will be performed pre and post LIFU application. Physiologic recordings will be recorded throughout.

Conditions

  • Autonomic Dysfunction

Interventions

DEVICE

Low-intensity focused ultrasound neuromodulation

ultrasound transducer applying low intensity waveforms to targeted brain regions for neuromodulation.

DEVICE

Sham Low-intensity focused ultrasound

sham application of ultrasound using blocking of the ultrasound waves of the transducer.

Sponsors & Collaborators

  • Virginia Polytechnic Institute and State University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2024-02-22
Primary Completion
2026-04-30
Completion
2026-12-30
FDA Device
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05834829 on ClinicalTrials.gov