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Correlation of Genetic Variations With Clinical Response in Substance Use Disorder

NCT05833399 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 200

Last updated 2023-04-27

No results posted yet for this study

Summary

This research outcomes can be summarized as follows:

1. Pharmacogenomic analysis of Substance Use Disorder (SUD) and medications used for the treatment of SUD.
2. Identification of novel genetic variations related to SUD specifically in the Egyptian population.
3. Validation of currently known genetic variations associated with SUD. When the functional interpretation of common or rare variants in studied genes becomes available, such pharmacogenomic information can be used to improve pharmacotherapy individualization.

Conditions

Interventions

DRUG

Quetiapine, olanzapine, mirtazapine, carbamazepine, sertraline, amitriptyline, chlorpromazine and risperidone

Medications are prescribed orally for outpatient or inpatient treatment of addicted patients.

Sponsors & Collaborators

  • Alexandria University

    lead OTHER

Principal Investigators

  • Sahar M El-Gowilly, PhD · Professor of Pharmacology and Toxicology, Alexandria University

  • Ahmed F El-Yazbi, PhD · Professor of Pharmacology and Toxicology, Alexandria University

  • Noha A Hamdy, PhD · Lecturer of Clinical Pharmacy and Pharmacy Practice, Alexandria University

  • Nefertiti A El-Nikhely, PhD · Associate Professor of Biochemistry, Alexandria University

  • Aymen H Hamouri, MSc · Psychiatrist Consultant

Eligibility

Min Age
20 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-11-28
Primary Completion
2024-03-31
Completion
2024-12-31
FDA Drug
Yes

Countries

  • Egypt

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05833399 on ClinicalTrials.gov