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Investigating Real-world Stress-related Mechanisms in Heavy Cannabis Users

NCT05833230 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2025-03-04

No results posted yet for this study

Summary

This research project proposes a novel approach to elucidate the biological adaptations associated with heavy cannabis use and to assess whether such adaptations are predictive of higher cannabis craving in response to both cannabis cues and stressors.

Conditions

  • Cannabis Use
  • Cannabis
  • Cannabis Abuse

Interventions

OTHER

Intensive Day Monitoring

During intake, a research assistant will demonstrate how to place the Heart Rate Variability monitor and provide instructions on completing the saliva samples at home. Participants will wear the Heart Rate Variability monitor for three consecutive, randomly selected days twice (72 hours each). Participants will be provided with six saliva sample collection tubes per day with explicit directions on when the saliva sampling should occur (hours since waking: +0, +1, +2, +4, +6, +10 hours, and before going to sleep). Participants will also complete a subjective report using similar questions included in the survey prompts at the same scheduled time as the saliva sample. All participants will complete a total of 6 such days during the study.

Sponsors & Collaborators

  • Robert E. Leet and Clara Guthrie Patterson Trust Mentored Research Award

    collaborator UNKNOWN

  • Yale University

    lead OTHER

Principal Investigators

  • Stephanie Wemm, PhD · Associate Research Scientist, Psychiatry

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-06-01
Primary Completion
2025-02-26
Completion
2025-02-26

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05833230 on ClinicalTrials.gov