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Brain Aging: Muscle-to-brain Axis Modulates Physio-cognitive Decline

NCT05828043 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 102

Last updated 2023-12-26

No results posted yet for this study

Summary

The primary goal is to develop a multidomain intervention program focused on preserving global or regional brain volume and functions while simultaneously improving physical mobility and cognitive functions in older individuals with mobility frailty. This initiative seeks to unravel the brain-muscle axis mechanisms contributing to the accelerated functional declines observed in older populations. Moreover, our objective includes examining the relationships between the intervention and a broad spectrum of clinical characteristics, phenotypic traits, biochemical profiles, myokines, proteomics, metabolomics, brain imaging, and our previously identified discoveries involving exosomal miRNA.

Conditions

  • Age-related Cognitive Decline
  • Age-related Physiology Decline

Interventions

BEHAVIORAL

Multi-domain intervention

Each session comprises of 45 minutes physical fitness activities targeting on muscle strength, balance, and flexibility; 1-hour cognitive training primarily on reasoning and memory exercises; and 15-minute for nutritional advices based on national diet guidelines for older adults

Sponsors & Collaborators

  • National Science and Technology Council

    collaborator FED

  • National Yang Ming Chiao Tung University

    lead OTHER

Principal Investigators

  • Liang-Kung Chen, M.D., PhD · Center for Healthy Longevity and Aging Sciences, National Yang Ming Chiao Tung University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-11-01
Primary Completion
2023-07-30
Completion
2023-07-30

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05828043 on ClinicalTrials.gov