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Vaginal Cuff Infiltration With Liposomal Bupivacaine for Pain Relief: A Double Blind, Randomized Controlled Trial

NCT05823363 · Status: WITHDRAWN · Phase: PHASE4 · Type: INTERVENTIONAL

Last updated 2026-04-03

No results posted yet for this study

Summary

The goal is to find out if Exparel (liposomal bupivacaine) given as an injection decreases pain score if given into the vaginal cuff right before starting the minimally invasive (robotic-assisted or laparoscopic) total hysterectomy in patients scheduled for benign indication? Participants will write down

1. pain score at various intervals
2. pain medication used Treatment patients will receive

1)intervention arm will receive Exparel mixed with bupivicaine 2)control arm will receive bupivicaine only

Conditions

  • Postoperative Pain

Interventions

DRUG

Exparel with Bubivacaine

10ml Exparel mixed with10ml bupivicaine in vaginal cuff

DRUG

Bupivacaine only

20ml of Bubivacaine in the vaginal cugg

Sponsors & Collaborators

  • Olivia Sher

    lead OTHER

Principal Investigators

  • Scott Chudnoff, MD · MMC

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-09
Primary Completion
2024-09-09
Completion
2024-09-09
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05823363 on ClinicalTrials.gov