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A Study to Assess the Effect of Dexpramipexole in Adolescents and Adults With Severe Eosinophilic Asthma (EXHALE-3)

NCT05813288 · Status: TERMINATED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 654

Last updated 2025-12-15

No results posted yet for this study

Summary

The objective of this clinical study is to investigate the safety, tolerability, and efficacy of dexpramipexole in participants with inadequately controlled severe eosinophilic asthma.

Conditions

Interventions

DRUG

Dexpramipexole Dihydrochloride

Oral administration of dexpramipexole tablet

DRUG

Placebo

Oral administration of placebo tablet

Sponsors & Collaborators

  • Areteia Therapeutics

    lead INDUSTRY

Principal Investigators

  • Michael E. Wechsler, MD · National Jewish Health

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
12 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-03-27
Primary Completion
2025-12-08
Completion
2025-12-08
FDA Drug
Yes

Countries

  • United States
  • Argentina
  • Austria
  • Brazil
  • Chile
  • China
  • Croatia
  • Czechia
  • France
  • Germany
  • Hungary
  • India
  • Israel
  • Italy
  • Japan
  • Lithuania
  • Mexico
  • Peru
  • Puerto Rico
  • South Africa
  • South Korea
  • Spain
  • Taiwan
  • Turkey (Türkiye)
  • Ukraine
  • United Kingdom

Study Locations

More Related Trials

Entities

Drugs
Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05813288 on ClinicalTrials.gov